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Wenjun Long Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Tuo Zhou Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Xiuping Xuan Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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Qiuli Cao Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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Zuojie Luo Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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Yingfen Qin Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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Qin Ning Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Xiaoping Luo Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Xuemei Xie Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

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growth (CG-IUGR) is much higher than that in normal people ( 10 , 11 ). Insulin resistance has been considered as an early manifestation as well as a crucial mechanism for metabolic disturbance in later life of individuals with CG-IUGR ( 12 , 13 , 14

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-21-0203
Volume/Issue:
Volume 11: Issue 1
Open access
Hong Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Jie Cao Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Jian-bin Su Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Xue-qin Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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Dong-mei Zhang Medical Research Center, Affiliated Hospital 2 of Nantong University, and First People’s Hospital of Nantong City, Nantong, China

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Xiao-hua Wang Department of Endocrinology, Affiliated Hospital 2 of Nantong University and First People’s Hospital of Nantong City, Nantong, China

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the formation of glycosylation end products (AGEs) collectively contribute to hypercoagulation in T2D ( 2 ). Insulin resistance, also termed 'reduced insulin sensitivity', is of central importance in the pathogenesis and progression of T2D and

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-21-0087
Volume/Issue:
Volume 10: Issue 7
Open access
Myrian Velasco Neuroscience Division, Department of Cognitive Neuroscience, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Rosa Isela Ortiz-Huidobro Neuroscience Division, Department of Cognitive Neuroscience, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Carlos Larqué Department of Embryology and Genetics, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

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Yuriko Itzel Sánchez-Zamora Neuroscience Division, Department of Cognitive Neuroscience, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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José Romo-Yáñez Department of Gynecological and Perinatal Endocrinology, Instituto Nacional de Perinatología ‘Isidro Espinosa de los Reyes’, Mexico City, Mexico

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Marcia Hiriart Neuroscience Division, Department of Cognitive Neuroscience, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City, Mexico

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central obesity (based on the waist circumference), dyslipidemia (decreased levels of high-density lipoprotein cholesterol, or hypertriglyceridemia), hypertension, impaired fasting glucose, and insulin resistance ( 5 ). MS diagnosis involves the presence

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-20-0288
Volume/Issue:
Volume 9: Issue 9
Open access
Huiyuan Zhai Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Dongxu Wang Department of Geriatrics, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Yong Wang Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Hongwei Gu Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Juan Jv Department of Cardiology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Liangliang Yuan Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Chao Wang Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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Leiyao Chen Department of Pharmacy, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Affiliated with Nanjing University of Chinese Medicine, Nanjing, China

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to form a characteristic feature known as a crown-like structure (CLS) ( 8 ). M1 macrophages in adipose tissue are considered instigators of insulin resistance due to the secretion of multiple pro-inflammatory cytokines, including TNFα ( 9 ). Chronic

Article Type:
Research Article
Collections:
Metabolic Syndrome and Diabetes
DOI:
https://doi.org/10.1530/EC-23-0379
Volume/Issue:
Volume 13: Issue 5
Open access
Stavroula A Paschou Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece

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Eleni Palioura Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece

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Dimitrios Ioannidis Department of Endocrinology and Diabetes, Sismanoglio-Amalia Fleming Hospital, Athens, Greece

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Panagiotis Anagnostis Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Argyro Panagiotakou Department of Endocrinology and Diabetes, Sismanoglio-Amalia Fleming Hospital, Athens, Greece

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Vasiliki Loi Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece

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Georgios Karageorgos Department of Endocrinology and Diabetes, Sismanoglio-Amalia Fleming Hospital, Athens, Greece

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Dimitrios G Goulis Unit of Reproductive Endocrinology, First Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Andromachi Vryonidou Department of Endocrinology and Diabetes, Hellenic Red Cross Hospital, Athens, Greece

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Introduction Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation and hyperandrogenism ( 1 ). It is often accompanied by insulin resistance ( 2 ) and abnormal lipid profile ( 3 , 4 ). Several studies have shown that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-17-0239
Volume/Issue:
Volume 6: Issue 8
Open access
Gunjan Garg Departments of Endocrinology, Obstetrics and Gynecology, Biostatics

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Garima Kachhawa Departments of Endocrinology, Obstetrics and Gynecology, Biostatics

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Rekha Ramot Departments of Endocrinology, Obstetrics and Gynecology, Biostatics

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Rajesh Khadgawat Departments of Endocrinology, Obstetrics and Gynecology, Biostatics

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Nikhil Tandon Departments of Endocrinology, Obstetrics and Gynecology, Biostatics

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V Sreenivas Departments of Endocrinology, Obstetrics and Gynecology, Biostatics

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Alka Kriplani Departments of Endocrinology, Obstetrics and Gynecology, Biostatics

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N Gupta Departments of Endocrinology, Obstetrics and Gynecology, Biostatics

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(1) . Vitamin D receptors are recognized to be present in numerous extra-skeletal tissues, including pancreas and muscle (2) . Vitamin D has been reported to influence not only insulin sensitivity/resistance (IS/IR) but also insulin secretion (3, 4

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-15-0001
Volume/Issue:
Volume 4: Issue 2
Open access
Monika Karczewska-Kupczewska Department of Internal Medicine and Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Agnieszka Nikołajuk Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland

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Radosław Majewski Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland

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Remigiusz Filarski Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland

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Magdalena Stefanowicz Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Natalia Matulewicz Department of Metabolic Diseases, Medical University of Białystok, Białystok, Poland

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Marek Strączkowski Department of Prophylaxis of Metabolic Diseases, Institute of Animal Reproduction and Food Research Polish Academy of Sciences, Olsztyn, Poland

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Introduction Obesity predisposes to the development of type 2 diabetes, dyslipidemia, hypertension, atherosclerosis, several types of cancer and other disorders. Insulin resistance is a major pathophysiological link between obesity and its

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0507
Volume/Issue:
Volume 9: Issue 2
Open access
Frederique Van de Velde Department of Endocrinology, Ghent University Hospital, Ghent, Belgium

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Marlies Bekaert Department of Endocrinology, Ghent University Hospital, Ghent, Belgium

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Anja Geerts Department of Hepatology, Ghent University Hospital, Ghent, Belgium

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Anne Hoorens Department of Pathology, Ghent University Hospital

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Arsène-Hélène Batens Department of Endocrinology, Ghent University Hospital, Ghent, Belgium

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Samyah Shadid Department of Endocrinology, Ghent University Hospital, Ghent, Belgium

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Margriet Ouwens Department of Endocrinology, Ghent University Hospital, Ghent, Belgium
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center at the Heinrich-Heine-University Duesseldorf, Leibniz Center for Diabetes Research, Duesseldorf, Germany
German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany

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Yves Van Nieuwenhove Department of Gastrointestinal Surgery, Ghent University Hospital, Ghent, Belgium

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Bruno Lapauw Department of Endocrinology, Ghent University Hospital, Ghent, Belgium

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methods are NAFLD Activity Score (NAS) and Steatosis, Activity, and Fibrosis (SAF) score ( 3 ). Importantly, patients with obesity who develop NAFLD are also more prone to develop other metabolic consequences of obesity such as insulin resistance (IR

Article Type:
Research Article
DOI:
https://doi.org/10.1530/EC-19-0366
Volume/Issue:
Volume 8: Issue 9
Open access
Vita Birzniece School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Garvan Institute of Medical Research, New South Wales, Australia
School of Medical Sciences, University of New South Wales, New South Wales, Australia

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Teresa Lam School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia
Department of Diabetes and Endocrinology, Westmead Hospital, New South Wales, Australia

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Mark McLean School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Navneeta Reddy Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Haleh Shahidipour School of Medicine, Western Sydney University, New South Wales, Australia
Department of Diabetes and Endocrinology, Blacktown Hospital, New South Wales, Australia

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Amy Hayden School of Medicine, Western Sydney University, New South Wales, Australia
Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia
Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia

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Howard Gurney Crown Princess Mary Cancer Centre, Westmead Hospital, New South Wales, Australia

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Glenn Stone School of Computing, Engineering and Mathematics, Western Sydney University, New South Wales, Australia

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Rikke Hjortebjerg Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark
Steno Diabetes Center Odense, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark

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Jan Frystyk Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Endocrine Research Unit, Department of Endocrinology, Odense University Hospital & Department of Clinical Research, Faculty of Health, University of Southern Denmark, Odense, Denmark

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hypogonadism, it is associated with the development of obesity, insulin resistance, hyperinsulinemia, and increased cardiovascular disease risk ( 1 , 2 ). The metabolic syndrome is present in >50% of men receiving long-term ADT compared to 20% of matched

Article Type:
Research Article
Collections:
Hormones and Cancer
DOI:
https://doi.org/10.1530/EC-21-0375
Volume/Issue:
Volume 11: Issue 4
Open access
Zheng Chen Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Haixia Zeng Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Qiulan Huang Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Cuiping Lin Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Xuan Li Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Shaohua Sun Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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Jian-ping Liu Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanchang University, Nanchang, China

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considered potential causes ( 6 ). However, increasing evidence ( 7 ) shows that insulin resistance and compensatory hyperinsulinemia play an important role in the pathogenesis of PCOS. The progression of insulin resistance as well as the regulation of

Article Type:
Research Article
Collections:
Reproduction
DOI:
https://doi.org/10.1530/EC-23-0428
Volume/Issue:
Volume 13: Issue 3
Open access