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Open access

Chiara Mele, Maria Teresa Samà, Alessandro Angelo Bisoffi, Marina Caputo, Valentina Bullara, Stefania Mai, Gillian Elisabeth Walker, Flavia Prodam, Paolo Marzullo, Gianluca Aimaretti, and Loredana Pagano

-sectional studies and confirmed in meta-analyses of cross-sectional and prospective studies. Many advocate that environmental and lifestyle factors, such as obesity and insulin resistance (IR), could be implicated in the pathogenesis of thyroid cancer ( 2 , 9 , 10

Open access

Annieke C G van Baar, Andrei Prodan, Camilla D Wahlgren, Steen S Poulsen, Filip K Knop, Albert K Groen, Jacques J Bergman, Max Nieuwdorp, and Evgeni Levin

/L) 1.45 0.65 1.25 0.69 HOMA-IR 4.53 1.95 4.36 2.18 BMI, body mass index; HbA1c, glycated hemoglobin A1c; HDL, high-density lipoprotein; HOMA-IR, homeostatic model assessment-insulin resistance; LDL, low

Open access

Ahmet Uçar, Nurçin Saka, Firdevs Baş, Nihal Hatipoğlu, Rüveyde Bundak, and Feyza Darendeliler

glucose (IFG) (22) . To determine insulin sensitivity (IS), homeostasis model assessment of insulin resistance (HOMA-IR) (fasting glucose (mg/dl)×insulin (mU/l)/405) (23) and IS index (ISI comp ) (Matsuda index=10 000/square root of ((fasting glucose

Open access

Hong-Fa Yan, Zhao-Yu Liu, Zhi-Ang Guan, and Chuang Guo

Introduction Type 2 diabetes mellitus (T2DM) is becoming one of the most pressing health issues facing society. Although T2DM is well described in terms of its hallmarks, namely insulin resistance and chronic hyperglycemia, the factors

Open access

Signe Frøssing, Malin Nylander, Caroline Kistorp, Sven O Skouby, and Jens Faber

Introduction Women with polycystic ovary syndrome (PCOS) are challenged with a metabolic aspect of the syndrome as they have increased prevalence of overweight with central obesity and insulin resistance. They present with an accumulation of

Open access

Amalie Carlsson, Kaspar Sørensen, Anna-Maria Andersson, Hanne Frederiksen, and Anders Juul

). Serious adverse health effects have been associated with high phthalate exposure such as alteration in reproductive development and increased risks of insulin resistance and obesity in human adults ( 8 , 9 , 10 , 11 , 12 ). Importantly, children may be

Open access

Chenghao Piao, Xiaojie Wang, Shiqiao Peng, Xinyu Guo, Hui Zhao, Li He, Yan Zeng, Fan Zhang, Kewen Zhu, and Yiwei Wang

foetus for development ( 5 ). The need for maternal insulin is an elevated result of gestational insulin resistance, which is impacted by attenuated food intake and placental hormone production. Consequently, the sizes of pancreatic β cells are enhanced

Open access

Karolien Van De Maele, Jean De Schepper, Jesse Vanbesien, Monique Van Helvoirt, Ann De Guchtenaere, and Inge Gies

directly by a direct vitamin D receptor-dependent inhibition of the critical molecular components of adipogenesis, as well indirectly by inducing insulin resistance and elevated PTH concentrations. Therefore, the main aim of our study is to investigate

Open access

Teresa Vilariño-García, Antonio Pérez-Pérez, Esther Santamaría-López, Nicolás Prados, Manuel Fernández-Sánchez, and Víctor Sánchez-Margalet

soluble leptin receptor levels and free leptin index in women with polycystic ovary syndrome: relationship to insulin resistance and androgens . Fertility and Sterility 2006 85 1441 – 1447 . ( ) 24

Open access

Karim Gariani, Geneviève Drifte, Irène Dunn-Siegrist, Jérôme Pugin, and François R Jornayvaz

-activated receptor α (PPARα) and PPARγ respectively (1, 6) . FGF21 has emerged as a key regulator in the metabolism of glucose and lipids (6, 7, 8) . FGF21 may have a potential role as a therapeutic agent for conditions associated with insulin resistance as it has