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Open access

I Savchuk, M L Morvan, J P Antignac, K Gemzell-Danielsson, B Le Bizec, O Söder and K Svechnikov

-placental unit . Endocrine Reviews 2011 32 317 – 355 . ( doi:10.1210/er.2010-0001 ) 2 Hanley NA Rainey WE Wilson DI Ball SG Parker KL. Expression profiles of SF-1, DAX1, and CYP17 in the human fetal adrenal gland: potential

Open access

Charlotte Höybye, Andreas F H Pfeiffer, Diego Ferone, Jens Sandahl Christiansen, David Gilfoyle, Eva Dam Christoffersen, Eva Mortensen, Jonathan A Leff and Michael Beckert

. Clinical safety parameters were stable with similar directional trends between TransCon GH and Omnitrope. After repeat doses, TransCon GH demonstrated a linear, dose-dependent increase in GH peak exposure without accumulation and a similar C max as

Open access

Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather M Stapleton and Heather B Patisaul

similarities with known neurotoxicants and endocrine-disrupting chemicals (EDCs), including PBDEs ( 9 ) and organophosphate pesticides ( 10 ), have raised concerns regarding possible health impacts, especially on the developing brain. Because we have found

Open access

Rachel K Rowe, Benjamin M Rumney, Hazel G May, Paska Permana, P David Adelson, S Mitchell Harman, Jonathan Lifshitz and Theresa C Thomas

-lasting neurological impairments. Clinically prevalent symptomology includes somatic, cognitive and emotional impairments, with chronic endocrine dysfunction becoming increasingly recognized as a clinical issue ( 3 , 4 , 5 ). Endocrine dysfunction after TBI can be

Open access

Renea A Taylor, Jennifer Lo, Natasha Ascui and Matthew J Watt

–29.9 are considered overweight, and those with a BMI >30 are considered obese. Excess adiposity is an epidemic in developed countries, with two in three men now defined as overweight or obese (4) . Compounding this upward trend is the increasing prevalence

Open access

Mieke Van Hemelrijck, Thurkaa Shanmugalingam, Cecilia Bosco, Wahyu Wulaningsih and Sabine Rohrmann

each s.d . increase in total and dairy protein and calcium intake, there was an increase in IGF1 concentration of 2.5, 2.4, and 3.3% respectively ( P for trend: <0.001 for all) and a decrease in IGFBP2 of 3.5, 3.5, and 5.4% respectively ( P for trend

Open access

Yang Lv, Ning Pu, Wei-lin Mao, Wen-qi Chen, Huan-yu Wang, Xu Han, Yuan Ji, Lei Zhang, Da-yong Jin, Wen-Hui Lou and Xue-feng Xu

, and unknown primary . Neuroendocrinology 2012 95 157 – 176 . ( ) 10.1159/000335597 22262022 12 O’Toole D. Current trend: endocrine tumors of the stomach, small bowel, colon and rectum . Gastroenterologie

Open access

Karim Gariani, Geneviève Drifte, Irène Dunn-Siegrist, Jérôme Pugin and François R Jornayvaz

deposition of heparansulfate proteoglycans and can be released into the circulation and function as endocrine factors (5) . FGF21 is a hormone mainly produced by the liver and white adipose tissue, where it is in part induced by the peroxisome proliferator

Open access

Nicolás Crisosto, Bárbara Echiburú, Manuel Maliqueo, Marta Luchsinger, Pedro Rojas, Sergio Recabarren and Teresa Sir-Petermann

Introduction Polycystic ovary syndrome (PCOS) is a common familial endocrine-metabolic disorder that affects women of reproductive age, characterized by irregular menses, chronic anovulation, infertility and hyperandrogenism ( 1 , 2 ). A

Open access

Fernando Aprile-Garcia, María Antunica-Noguerol, Maia Ludmila Budziñski, Ana C Liberman and Eduardo Arzt

component of the endocrine stress response. IL1 and other cytokines act on the brain via several communication pathways: i) primary afferent neurons that innervate the periphery; ii) a humoral pathway that involves production of proinflammatory cytokines by