Kathryn L Gatford
Kathryn L Gatford
Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia
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Adelaide Medical School, The University of Adelaide, Adelaide, Australia
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Beverly S Muhlhausler
Beverly S Muhlhausler
FOOD plus Research Centre, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia
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Lili Huang
Lili Huang
School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia
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Pamela Su-Lin Sim
Pamela Su-Lin Sim
FOOD plus Research Centre, School of Agriculture, Food and Wine, The University of Adelaide, Adelaide, Australia
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Claire T Roberts
Claire T Roberts
Robinson Research Institute, The University of Adelaide, Adelaide, Australia
Adelaide Medical School, The University of Adelaide, Adelaide, Australia
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Adelaide Medical School, The University of Adelaide, Adelaide, Australia
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Johannes D Velhuis
Johannes D Velhuis
Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota, USA
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Chen Chen
Chen Chen
School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, Australia
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GH in non-pregnant female mice and throughout murine pregnancy. Methods Animals Experimental procedures were approved by the University of Adelaide Animal Ethics Committee (M-2014-167) and carried out in accordance with the Australian code
L Ghataore
L Ghataore
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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I Chakraborti
I Chakraborti
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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S J Aylwin
S J Aylwin
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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K-M Schulte
K-M Schulte
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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D Dworakowska
D Dworakowska
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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P Coskeran
P Coskeran
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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N F Taylor
N F Taylor
Departments of, Clinical Biochemistry, Medicine, Department of Endocrinology and Internal Medicine, King's College Hospital, London SE5 9RS, UK
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Pharma, Paris, France) and oral hydrocortisone (six males: range 26–66 years, median 50 years and 11 females: range 20–76 years, median 47 years (six of premenopausal age)) and patients receiving hydrocortisone only after surgery in the period before
Kate E Lines
Kate E Lines
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Mahsa Javid
Mahsa Javid
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Anita A C Reed
Anita A C Reed
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Gerard V Walls
Gerard V Walls
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Mark Stevenson
Mark Stevenson
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Michelle Simon
Michelle Simon
MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK
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Kreepa G Kooblall
Kreepa G Kooblall
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Sian E Piret
Sian E Piret
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Paul T Christie
Paul T Christie
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Paul J Newey
Paul J Newey
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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Ann-Marie Mallon
Ann-Marie Mallon
MRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Oxfordshire, UK
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Rajesh V Thakker
Rajesh V Thakker
Academic Endocrine Unit, Radcliffe Department of Medicine, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Headington, Oxford, UK
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1 syndrome in patients. However, the frequency of tumour development and age of onset depended on the background strain and sex of the mice. Thus, overall, more pituitary tumours developed in female C57BL/6 Men1 +/- mice than in female 129S6/SvEv
Qiankai Jin
Qiankai Jin
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Guoqing Huang
Guoqing Huang
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Xiaoqing Tian
Xiaoqing Tian
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Yimeng Shu
Yimeng Shu
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Ximisinuer Tusongtuoheti
Ximisinuer Tusongtuoheti
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
School of Medicine, Ningbo University, Ningbo, China
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School of Medicine, Ningbo University, Ningbo, China
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Yushan Mao
Yushan Mao
Department of Endocrinology, The Affiliated Hospital of Medical School, Ningbo University, Ningbo, China
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combination with the actual situation of WC in the Chinese population ( 1 , 16 ). For each component, the diagnostic criteria were as follows: (i) central obesity (WC ≥ 90 cm in males and ≥ 85 cm in females), (ii) hypertriglyceridemia (TGs ≥ 1.7 mmol/L (150
Sayaka Kawano
Sayaka Kawano
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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Yukiko Kawagoe
Yukiko Kawagoe
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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Kenji Kuwasako
Kenji Kuwasako
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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Satoshi Shimamoto
Satoshi Shimamoto
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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Koji Igarashi
Koji Igarashi
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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Mariko Tokashiki
Mariko Tokashiki
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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Kazuo Kitamura
Kazuo Kitamura
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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Johji Kato
Johji Kato
Frontier Science Research Center, Circulatory and Body Fluid Regulation, AIA Research Group, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan
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2013, were randomly selected for this study (172 males and 174 females; 62.0±8.9 years, mean± s.d .). Upon visiting the community center of Kiyotake Town, the medical history of the residents, which included the questionnaire of whether or not they have
Lukas Engler
Lukas Engler
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany
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Christian Adolf
Christian Adolf
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany
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Daniel A Heinrich
Daniel A Heinrich
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany
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Anna-Katharine Brem
Anna-Katharine Brem
Max-Planck-Institute of Psychiatry, Munich, Germany
Division of Interventional Cognitive Neurology, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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Division of Interventional Cognitive Neurology, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
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Anna Riester
Anna Riester
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany
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Anna Franke
Anna Franke
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany
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Felix Beuschlein
Felix Beuschlein
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany
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Martin Reincke
Martin Reincke
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany
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Axel Steiger
Axel Steiger
Max-Planck-Institute of Psychiatry, Munich, Germany
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Heike Künzel
Heike Künzel
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, Germany
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Introduction Patients with primary aldosteronism (PA) are thought to be a natural model for chronic aldosterone excess, showing significantly higher scores for depression and anxiety compared to the general population, with females being more
Alan D Rogol
Alan D Rogol
Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA
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). The Leydig cell also produces insulin-like factor 3, an important component acting in concert with testosterone to promote testicular descent ( 21 ). The female fetus lacks AMH, permitting the Müllerian structures to remain, and lacks the
Estelle Bonnet
Estelle Bonnet
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service d’endocrinologie pédiatrique, Bron, France
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Mathias Winter
Mathias Winter
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de psychopathologie du développement, Bron, France
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Centre de biologie et pathologie Est, Service d’hormonologie, d’endocrinologie moléculaire et des maladies rares, Bron, France
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Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de psychopathologie du développement, Bron, France
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Centre de biologie et pathologie Est, Service d’hormonologie, d’endocrinologie moléculaire et des maladies rares, Bron, France
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Delphine Mallet
Delphine Mallet
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Centre de biologie et pathologie Est, Service d’hormonologie, d’endocrinologie moléculaire et des maladies rares, Bron, France
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Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Centre de biologie et pathologie Est, Service d’hormonologie, d’endocrinologie moléculaire et des maladies rares, Bron, France
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Ingrid Plotton
Ingrid Plotton
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service Endocrinologie Moléculaire et Maladies Rares, Bron, France
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Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service Endocrinologie Moléculaire et Maladies Rares, Bron, France
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Claire Bouvattier
Claire Bouvattier
Centre Hospitalier Universitaire AP-HP, Hôpital Bicêtre, Service d’endocrinologie pédiatrique Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN Université Paris Saclay, Le Kremlin-Bicêtre, France
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Maryse Cartigny
Maryse Cartigny
Centre Hospitalier Régional Universitaire Lille, Hôpital Jeanne de Flandre, Unité d’Endocrinologie pédiatrique Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Lille, France
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Laetiti Martinerie
Laetiti Martinerie
Centre Hospitalier Universitaire AP-HP, Hôpital Robert Debré, Service d’Endocrinologie pédiatrique Centre de Référence des Maladies Rares Endocriniennes de la Croissance et du Développement – CRMERC Université de Paris, Paris, France
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Michel Polak
Michel Polak
Centre Hospitalier Universitaire AP-HP, Hôpital universitaire Necker Enfants malades, Endocrinologie gynécologie diabétologie pédiatriques Centre de référence des maladies endocriniennes rares de la croissance et du développement Inserm U1016, institut Imagine, Paris, France
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Anne Bachelot
Anne Bachelot
Centre Hospitalier Universitaire AP-HP, Hôpital Pitié Salpêtrière, Department of Endocrinology and Reproductive Medicine Centre de Référence des Maladies Endocriniennes Rares de la Croissance et du Développement Centre de Référence des pathologies gynécologiques rares IE3M, Paris, France
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Frédéric Huet
Frédéric Huet
Centre Hospitalier Universitaire Dijon-Bourgogne, Hôpital d’Enfants, Service de Pédiatrie Multidisciplinaire, Dijon, France
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Sabine Baron
Sabine Baron
Centre Hospitalier universitaire de Nantes, Hôpital Mère-Enfant, Service de Pédiatrie, Nantes, France
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Muriel Houang
Muriel Houang
Centre Hospitalier Universitaire AP-HP, Hôpital Armand Trousseau, Service d'Explorations Fonctionnelles Endocriniennes, Paris, France
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Sylvie Soskin
Sylvie Soskin
Hôpitaux Universitaires de Strasbourg, CHU Hautepierre, Service de Pédiatrie 1, Strasbourg, France
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Anne Lienhardt
Anne Lienhardt
Centre hospitalier universitaire Limoges, Hôpital de la Mère et de l’enfant, Service de Pédiatrie, Limoges, France
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Jérôme Bertherat
Jérôme Bertherat
Groupement Hospitalier Universitaire de Paris, AP-HP, Hôpital Cochin, Service d'Endocrinologie, Paris, France
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Cyril Amouroux
Cyril Amouroux
Centre Hospitalier Universitaire de Montpellier, Hôpital Lapeyronie, Service de Néphrologie et Endocrinologie Pédiatrique Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Montpellier, France
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Aurore Bouty
Aurore Bouty
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de chirurgie Uro-viscérale et de Transplantation de l’Enfant, Bron, France
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Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de chirurgie Uro-viscérale et de Transplantation de l’Enfant, Bron, France
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Lise Duranteau
Lise Duranteau
AP-HP, Hôpital Bicêtre, Unité de gynécologie de l’adolescente Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN Université Paris Saclay, Le Kremlin-Bicêtre, France
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Rémi Besson
Rémi Besson
Centre Hospitalier Régional Universitaire Lille, Hôpital Jeanne de Flandre, Service de chirurgie pédiatrique Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Lille, France
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Alaa El Ghoneimi
Alaa El Ghoneimi
Centre Hospitalier Universitaire AP-HP Robert Debré, Service de Chirurgie Viscérale et Urologie pédiatrique Centre de Référence des Maladies Endocriniennes de la croissance et du développement – CRMERC Université de Paris, Paris, France
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Dinane Samara-Boustani
Dinane Samara-Boustani
Centre Hospitalier Universitaire AP-HP, Hôpital Necker Enfants malades, Endocrinologie gynécologie diabétologie pédiatriques Centre de référence des maladies endocriniennes rares de la croissance et du développement, Paris, France
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François Becmeur
François Becmeur
Hospitaux Universitaires de Strasbourg, CHU Hautepierre, Service de chirurgie pédiatrique, Strasbourg, France
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Nicolas Kalfa
Nicolas Kalfa
Centre Hospitalier Universitaire de Montpellier, Hôpital Lapeyronie, Service de Chirurgie Viscérale et Urologie Pédiatrique Centre National de Référence Maladies Rares du Développement Génital Constitutif Sud Institut Debrest de Santé Publique IDESP, UMR INSERM, Université de Montpellier, Montpellier, France
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Françoise Paris
Françoise Paris
Centre Hospitalier Universitaire de Montpellier, Hôpital Lapeyronie, Service de Néphrologie et Endocrinologie Pédiatrique Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Montpellier, France
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François Medjkane
François Medjkane
Centre Hospitalier Régional Universitaire Lille, Hôpital Jeanne de Flandre, Service de psychiatrie de l’enfant et de l’adolescent Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Lille, France
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Aude Brac de la Perrière
Aude Brac de la Perrière
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Hospices Civils de Lyon, Groupement Hospitalier Est, Service d’endocrinologie, Bron, France
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Hospices Civils de Lyon, Groupement Hospitalier Est, Service d’endocrinologie, Bron, France
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Patricia Bretones
Patricia Bretones
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service d’endocrinologie pédiatrique, Bron, France
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
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Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
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Hervé Lejeune
Hervé Lejeune
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de médecine de la reproduction, Bron, France
Université Claude Bernard, Lyon, France
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Université Claude Bernard, Lyon, France
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Marc Nicolino
Marc Nicolino
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service d’endocrinologie pédiatrique, Bron, France
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Université Claude Bernard, Lyon, France
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Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Université Claude Bernard, Lyon, France
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Pierre Mouriquand
Pierre Mouriquand
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de chirurgie Uro-viscérale et de Transplantation de l’Enfant, Bron, France
Université Claude Bernard, Lyon, France
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Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de chirurgie Uro-viscérale et de Transplantation de l’Enfant, Bron, France
Université Claude Bernard, Lyon, France
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Daniela-Brindusa Gorduza
Daniela-Brindusa Gorduza
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de chirurgie Uro-viscérale et de Transplantation de l’Enfant, Bron, France
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Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service de chirurgie Uro-viscérale et de Transplantation de l’Enfant, Bron, France
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Claire-Lise Gay
Claire-Lise Gay
Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Service d’endocrinologie pédiatrique, Bron, France
Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
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Centre National de Référence Maladies Rares du développement génital du fœtus à l’adulte DEV-GEN, Hospices Civils de Lyon, Bron, France
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deficiency (HSD17B3). These two rare autosomal recessive conditions display a great heterogeneity at both the genotypic and phenotypic levels ( 1 , 2 , 3 , 4 , 5 , 6 ). Clinical presentations of external genitalia at birth range from a female appearance
Yael Sofer
Yael Sofer
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Nava Nevo
Nava Nevo
Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel
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Michal Vechoropoulos
Michal Vechoropoulos
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Gabi Shefer
Gabi Shefer
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Etty Osher
Etty Osher
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Nathan Landis
Nathan Landis
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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Karen Tordjman
Karen Tordjman
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Geoffrey L Hammond
Geoffrey L Hammond
Departments of Cellular & Physiological Sciences and Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
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Naftali Stern
Naftali Stern
Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv-Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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of gestational diabetes as early as 11–13 weeks of gestation ( 15 ). Of note, several studies have shown that the relationship between SHBG levels and diabetes is independent of sex hormones, in both female and male subjects ( 16 , 17 , 18 ). In a
Sarmistha Banerjee
Sarmistha Banerjee
Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Allison M Hayes
Allison M Hayes
Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Bernard H Shapiro
Bernard H Shapiro
Department of Biomedical Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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, males and females express different CYP profiles. In some cases, the isoforms may be sex exclusive as is the case of CYP2C12, only expressed in female rats ( 1 , 2 ). More commonly, isoforms are sex predominant: for example, women express greater levels
