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exocrine and endocrine portions of the tumor are derived from the bidirectional differentiation of a common stem cell ( 8 , 9 , 10 , 11 ). Stanniocalcin 1 (STC1) is a 56-kD homodimeric protein with autocrine and paracrine functions that protect cells
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investigate PTC. In the present study, it was found that FOXP4 was highly expressed in THCA, and through the ROC curve analysis, it was suggested that FOXP4 might be used as a biomarker for diagnosing THCA. Currently, investigation on cancer stem cells shows
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Desrochers LM Bordeleau F Reinhart-King CA Cerione RA Antonyak MA . Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation . Nature Communications 2016 7 11958 . ( https
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(PHGDH), an important enzyme in serine biosynthesis, is associated with proliferation, tumorigenesis, and stemness of thyroid cancer cells ( 4 ). As PHGDH expression resulted in aggressive thyroid cancers, it might be a potential therapeutic target ( 4
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mechanisms between cells of hematopoietic stem cell origin and cells of mesenchymal stem cell origin. This difference might provide a basis for new tissue-specific or cell-specific pharmacotherapeutic utilization of glucocorticoids, β-agonists and β
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ubiquitination of TRAF3 ( 21 ). Laura Novellasdemunt et al. reported that NEDD4 and NEDD4L regulate Wnt signaling and intestinal stem cell priming by degrading the LGR5 receptor ( 33 ). In the current study, we found that GPX4 is the direct target of NEDD4L
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Hematology and Oncology 2022 15 129 . ( https://doi.org/10.1186/s13045-022-01347-8 ) 33 Jin W . Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial
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