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Open access

Yali Cheng, Qiaoying Lv, Bingying Xie, Bingyi Yang, Weiwei Shan, Chengcheng Ning, Bing Li, Liying Xie, Chao Gu, Xuezhen Luo, Xiaojun Chen and Qin Zhu

endogenous or exogenous estrogen exposure without progesterone protection is the leading cause of type1 EC ( 2 , 3 ). Accumulating epidemiological evidence also demonstrated that insulin resistance was highly prevalent in endometrial cancer ( 4 , 5 , 6

Open access

Gunjan Garg, Garima Kachhawa, Rekha Ramot, Rajesh Khadgawat, Nikhil Tandon, V Sreenivas, Alka Kriplani and N Gupta

(1) . Vitamin D receptors are recognized to be present in numerous extra-skeletal tissues, including pancreas and muscle (2) . Vitamin D has been reported to influence not only insulin sensitivity/resistance (IS/IR) but also insulin secretion (3, 4

Open access

Anna Kistner, Mireille Vanpée and Kerstin Hall

(defined as birth weight (BW) below 2500 g) has been proposed to lead to insulin resistance and type 2 diabetes (1, 2, 3, 4) . In studies of individuals born SGA at term (defined as BW SDS below −2 SDS), signs of insulin resistance have been detected in

Open access

L Ahlkvist, K Brown and B Ahrén

Introduction In fully compensated insulin resistance, there is a sufficient upregulation of insulin secretion whereas in glucose intolerance and type 2 diabetes this upregulation is inadequate (1) . Several mechanisms have been suggested to

Open access

Dorte Glintborg, Hanne Mumm, Jens Juul Holst and Marianne Andersen

Introduction Polycystic ovary syndrome (PCOS) is characterized by oligo/anovulation, hyperandrogenaemia and polycystic ovaries ( 1 , 2 ). Hyperinsulinaemia as a consequence of insulin resistance is present in most patients with PCOS ( 1

Open access

Patricia Iozzo and Maria Angela Guzzardi

exerted by obesity on cognitive dysfunction and vice versa. Both have been associated with morphological reductions in brain volume, relating to systemic dysmetabolism and insulin resistance and/or to the degree of cognitive impairment ( 21 , 22 , 23

Open access

Monika Karczewska-Kupczewska, Agnieszka Nikołajuk, Radosław Majewski, Remigiusz Filarski, Magdalena Stefanowicz, Natalia Matulewicz and Marek Strączkowski

Introduction Obesity predisposes to the development of type 2 diabetes, dyslipidemia, hypertension, atherosclerosis, several types of cancer and other disorders. Insulin resistance is a major pathophysiological link between obesity and its

Open access

Nicolás Crisosto, Bárbara Echiburú, Manuel Maliqueo, Marta Luchsinger, Pedro Rojas, Sergio Recabarren and Teresa Sir-Petermann

groups ( 14 ). Regarding metabolic features, we observed increased weight from an early age and some indicators of insulin resistance during adulthood ( 12 ). Puberty is a transition period between childhood and adulthood accompanied by profound changes

Open access

Thozhukat Sathyapalan, Anne-Marie Coady, Eric S Kilpatrick and Stephen L Atkin

reduction in insulin resistance especially with weight loss in patients with T2DM will result in normalisation of pancreatic β-cell requirement and even reversal of T2DM ( 9 ). Statins have shown to improve certain features of polycystic ovary syndrome

Open access

Amalie R Lanng, Lærke S Gasbjerg, Natasha C Bergmann, Sigrid Bergmann, Mads M Helsted, Matthew P Gillum, Bolette Hartmann, Jens J Holst, Tina Vilsbøll and Filip K Knop

may cause hepatic steatosis which in some individuals leads to insulin resistance and impaired glucose tolerance ( 4 , 5 ). However, the exact mechanisms underlying these pathophysiological processes have not been identified. Alcohol has been found