Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France
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Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France
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Department of Endocrinology, Diabetes and Metabolic Diseases, Normandie Univ, UNIROUEN, Rouen University Hospital, Rouen, France
Centre d’Investigation Clinique (CIC-CRB)-INSERM 1404, Rouen University Hospital, Rouen, France
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neuropeptidergic system in the control of glucose homeostasis has been reported. It was found that 26RFa and GPR103 are expressed by the pancreatic islets as well as by various insulin-secreting cell lines ( 23 , 24 ) and that the neuropeptide prevents cell death
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centrifuged at 4000 g for5.5 min at 4°C, plasma separated, aliquoted, and stored at −80°C for future analyses.Amylin, C-peptide, glucagon, glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, pancreatic polypeptide, and
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
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Center for Biochemistry, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany
Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany
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0.0421 a Yes = 38No = 39 0.106 0.359 Yes = 38No = 39 Smoking before pregnancy X −0.293 W 0 . 0102 a Yes = 35No = 41 −0.288 W 0 . 0116 a Yes = 35No = 41 Insulin (mU/L) 13.35 ± 9.020.50/61.40 0.085 0.482 71 0
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physical activity program ( 9 , 10 ). If glycemic goals were not reached after these measures, pharmacological therapy should be started ( 9 , 10 ). For many years, insulin has been used to safely and effectively treat GDM ( 11 ). More recently
Department of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Introduction Since insulin was discovered by Banting and Best in the 1920s, it has been used for diabetes therapy and has achieved significant therapeutic effects. However, some immunological responses to exogenous insulin have been found ( 1
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Introduction After the discovery, in 1959, of the radioimmunoassay which enabled the measurement of insulin in human plasma ( 1 ), circulating metabolic hormones such as insulin ( 2 ) or growth hormone ( 3 , 4 ) were quickly investigated for
Monash Centre for Health Research and Implementation, Monash University, Clayton, Victoria, Australia
Australian Institute for Musculoskeletal Science, Victoria University, Melbourne, Victoria, Australia
Medicine-Western Health, Faculty of Medicine, Dentistry and Health Science, Melbourne University, Melbourne, Victoria, Australia
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Australian Institute for Musculoskeletal Science, Victoria University, Melbourne, Victoria, Australia
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Division of Diabetes, Endocrinology & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
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Diabetes and Endocrine Units, Monash Health, Clayton, Victoria, Australia
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anovulatory infertility) ( 5 , 6 ) and psychological (anxiety and depression) ( 7 ) impacts, representing a substantial health burden. Despite its high prevalence, the aetiology and ideal therapies for PCOS remain unclear ( 8 ). Insulin resistance is a
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conditions, such as fusion and fission, mitophagy as well as mitochondrial biogenesis. All of these will be discussed in the following sections, mainly in relation to changes in the obese state and under conditions of impaired insulin action (i.e. insulin
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600968) of the distal convoluted tubule (DCT) ( 2 ). Recently ( 3 ), impaired glucose metabolism and insulin sensitivity were reported in GS patients, but insulin secretion function has not been studied in this population. Due to the lack of research in
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, we recently performed a trial in which we administered bromocriptine, for 2 weeks, in the evening in 8 lean, healthy subjects. Unexpectedly, these lean healthy subjects became less insulin sensitive after using bromocriptine ( 11 ). This adverse