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Open access

Wang Chengji and Fan Xianjin

Introduction Smoking ( 1 ), low physical activity ( 2 ), obesity, insulin resistance and hyperglycemia ( 3 ) are independently associated with incident type 2 diabetes mellitus (T2DM). Insulin resistance is affected by metabolic risk factors

Open access

Vittorio Unfer, Fabio Facchinetti, Beatrice Orrù, Barbara Giordani, and John Nestler

) 17035995 10.1038/nature05185 3 Paul C Laganà AS Maniglio P Triolo O Brady DM. Inositol’s and other nutraceuticals’ synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state

Open access

Janaína Felix Braga, Daniela Ravizzoni Dartora, Natalia Alenina, Michael Bader, and Robson Augusto Souza Santos

. Diabetes mellitus is characterized by insulin insufficiency due to either decreased insulin release or end organ insulin resistance. Among the major existing categories of diabetes, type I (T1DM) usually occurs in children and young adults and is

Open access

Jiayang Lin, Peizhen Zhang, Yan Huang, Xueyun Wei, Dan Guo, Jianfang Liu, Deying Liu, Yajuan Deng, Bingyan Xu, Chensihan Huang, Xiaoyu Yang, Yan Lu, Lijing Jia, and Huijie Zhang

methods with automatic multichannel chemical analyzer (Hitachi 7450). Low-density lipoprotein cholesterol (LDL-c) was calculated by Friedewald’s formula: TC (mmol/L) − HDL-c (mmol/L) − TG (mmol/L)/2.2 ( 26 ). Insulin resistance status was assessed using

Open access

Kim K B Clemmensen, Jonas S Quist, Dorte Vistisen, Daniel R Witte, Anna Jonsson, Oluf Pedersen, Torben Hansen, Jens J Holst, Torsten Lauritzen, Marit E Jørgensen, Signe Torekov, and Kristine Færch

.9% among in-patients, suggesting that the effect of weekend behavior is likely to be attenuated when hospitalized ( 14 ). In a study of 807 Danish children with up to three different visit days, a marker of insulin resistance in the fasting state was found

Open access

Hugo R Ramos, Andreas L Birkenfeld, and Adolfo J de Bold

bodyweight as well as with insulin resistance and T2D (19, 74, 75, 76, 77, 78) ( Table 1 ). This correlation can also be observed in patients with congestive heart failure, despite increased cNP levels, due to cardiac wall stress (79) . Several

Open access

Helga Schultz, Svend Aage Engelholm, Eva Harder, Ulrik Pedersen-Bjergaard, and Peter Lommer Kristensen

(MSCC) and brain tumours. Diabetes mellitus (DM) is a well-known metabolic side effect from treatment with glucocorticoids. The diabetogenic effect is mainly a result of insulin resistance in muscle and fatty tissue, increased production of glucose from

Open access

Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Stefan A Wudy, Zbigniew Olczak, Katarzyna Gruszczynska, and Ze’ev Hochberg

.5) were calculated as indices of insulin resistance. Cortisol was measured in the morning (08:00 h) and midnight using chemiluminescent immunoassay by Immulite 2000 analyzer (DPC, USA). Serum concentrations of fT4 and TSH were measured with a

Open access

Ling-Jun Li, Izzuddin M Aris, Lin Lin Su, Yap Seng Chong, Tien Yin Wong, Kok Hian Tan, and Jie Jin Wang

, 3 ). The diagnosis of GDM identifies women with insulin resistance (targeted cell resistance to the activity of insulin) and/or β-cell dysfunction (insufficient secretion of insulin by the pancreatic β-cells to compensate for peripheral insulin

Open access

M A Webb, H Mani, S J Robertson, H L Waller, D R Webb, C L Edwardson, D H Bodicoat, T Yates, K Khunti, and M J Davies

to insulin resistance ( 9 , 10 ). Indeed experimental studies in healthy subjects have demonstrated that IL6 injections increase blood glucose without any changes in C-peptide levels, suggesting that IL6 directly reduces insulin sensitivity ( 11