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Open access

Estíbaliz Castillero, Ana Isabel Martín, Maria Paz Nieto-Bona, Carmen Fernández-Galaz, María López-Menduiña, María Ángeles Villanúa, and Asunción López-Calderón

most RA patients have increased basal plasma insulin levels and insulin resistance (24) , arthritic rats have lower serum insulin levels. In this sense, several factors account for the increased incidence of insulin resistance in RA that are not shared

Open access

Qiu-ming Yao, Bin Wang, Xiao-fei An, Jin-an Zhang, and Liumei Ding

have been proposed to explain the association between testosterone and diabetes ( 50 , 51 ). Firstly, the key role of insulin resistance in the pathogenesis of T2DM has been well established. Previous studies have proven the inverse association between

Open access

Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, Riitta Parkkola, Vesa Oikonen, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop, and Pirjo Nuutila

.2–3.2) 2-h OGIS, oral glucose insulin sensitivity index; GIP, glucose-dependent insulinotrophic peptide; GLP-1, glucagon-like peptide 1; HbA1c, glycated hemoglobin; HOMA IR , homeostatic model assessment for insulin resistance; ISR, insulin secretion rate

Open access

Huguette S Brink, Aart Jan van der Lely, and Joke van der Linden

incidence of GD is increasing in line with the global rise of obesity and type 2 diabetes mellitus (T2DM) ( 2 ). GD occurs when &-cells cannot compensate for the increased levels of insulin resistance ( 3 ). Insulin resistance and &-cell dysfunction are two

Open access

Jia Li, Yan Zhao, Caoxin Huang, Zheng Chen, Xiulin Shi, Long Li, Zhong Chen, and Xuejun Li

Metabolite overview of the set of enriched biomarkers. Discussion NAFLD is considered a hepatic manifestation of metabolic syndrome and is strongly associated with insulin resistance ( 15 , 16 ). Our previous clinical trial contributed

Open access

Shane M Regnier, Andrew G Kirkley, Daniel Ruiz, Wakanene Kamau, Qian Wu, Kurunthachalam Kannan, and Robert M Sargis

have shown that TF augments adipogenesis in vitro ( 18 ) and promotes insulin resistance in rodent and human adipose tissues exposed ex vivo ( 19 ). These effects are postulated to result from activation of adipocytic glucocorticoid receptor (GR

Open access

Sandrine Visentin, Gérard Michel, Claire Oudin, Béatrice Cousin, Bénédicte Gaborit, Inès Abdesselam, Marie Maraninchi, Marion Nowicki, René Valéro, Maxime Guye, Monique Bernard, Pascal Auquier, Hervé Chambost, Marie-Christine Alessi, and Sophie Béliard

with significantly more pronounced insulin resistance parameters (higher triglycerides, higher plasma glucose levels and lower HDL-C levels) despite lower BMIs and lower waist circumferences when compared to controls ( 15 ). MS is the clinico

Open access

C L Bodinham, L Smith, E L Thomas, J D Bell, J R Swann, A Costabile, D Russell-Jones, A M Umpleby, and M D Robertson

. This was highlighted in a scientific advisory committee (SACN) statement on nutrition that stated, although cereal fiber intake has been associated with a reduced incidence of type 2 diabetes (T2DM) and metabolic risk factors such as insulin resistance

Open access

Maria Lola Evia-Viscarra, Edel Rafael Rodea-Montero, Evelia Apolinar-Jiménez, and Silvia Quintana-Vargas

accelerate the development of early atherosclerosis beginning in childhood (10) . In both children and adults with obesity and MS, insulin resistance (IR) and chronic inflammation appear to be responsible for the changes that induce complications or

Open access

Ermina Bach, Niels Møller, Jens Otto L Jørgensen, Mads Buhl, and Holger Jon Møller

in sCD163 are seen in conditions of low-grade inflammation, such as obesity, insulin resistance and type 2 diabetes mellitus (T2D) ( 17 , 18 , 19 , 20 ), but it is not known if these changes are directly linked to low-grade endotoxinemia or they