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Open access

Katica Bajuk Studen and Marija Pfeifer

aim of this article is to explore and review current evidence that associates PCOS with cardiometabolic abnormalities and possibly an increased risk of cardiovascular disease. Insulin resistance, metabolic syndrome, obesity and sleep disturbances

Open access

Nafiye Helvaci, Erdem Karabulut, Ahmet Ugur Demir, and Bulent Okan Yildiz

fully understood, obesity, insulin resistance and hyperandrogenemia, which are the main features of PCOS, are all proposed to play a role in the development of OSA in patients with PCOS. The objective of this meta-analysis was to examine if there is an

Open access

Meena Asmar, Ali Asmar, Lene Simonsen, Flemming Dela, Jens Juul Holst, and Jens Bülow

glucose disposal ( 27 , 28 ). It recruits microvasculature in the muscle by relaxing terminal arterioles thereby expanding the microvascular blood flow ( 20 , 21 , 29 ). Furthermore, insulin induces relaxation of resistance vessels and causes an

Open access

Alessandra Gambineri and Carla Pelusi

development of T2DM in PCOS ( 17 ). These data support the most widely accepted hypothesis that the increased risk of T2DM in PCOS is mainly related to the strong interaction between androgens, obesity and peripheral insulin resistance. Animal studies

Open access

Julia Modesto Vicente, Junia Carolina Santos-Silva, Caio Jordão Teixeira, Dailson Nogueira de Souza, Jean Franciesco Vettorazzi, Fabiola Sales Furtuoso, Isabel Gouveia Adabo, Fabio Takeo Sato, Marco Aurélio Ramirez Vinolo, Everardo Magalhães Carneiro, Silvana Bordin, and Gabriel Forato Anhê

infiltrated in adipose fat pads Macrophages infiltrated in distinct adipose fat pads are recognized to produce several interleukins that are able to cause insulin resistance ( 17 ). Adipose tissue macrophages (ATM) can assume two distinct phenotypes, the M1

Open access

Chunliang Yang, Junyi Li, Fei Sun, Haifeng Zhou, Jia Yang, and Chao Yang

gluconeogenesis. Specifically, in the long run, metabolic disorders that are responsible for insulin resistance may also, in turn, damage the insulin-secreting capability of islet β cells through the accumulation of proinflammatory cytokines and toxic lipids ( 1

Open access

Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo, and Carla Giordano

). Blood samples were collected every 30 min for 2 h for glucose and insulin measurements. As surrogate estimates of insulin sensitivity we considered the homeostasis model assessment estimate of insulin resistance (Homa-IR) ( 19 ) and the insulin

Open access

Emanuela Zaharieva, Zdravko Kamenov, Tsvetelina Velikova, Adelina Tsakova, Yosif El-Darawish, and Haruki Okamura

associated with a chronic low-grade inflammation ( 5 ) that has been implicated as a crucial factor for insulin resistance ( 6 ) and also beta-cell dysfunction ( 7 , 8 ). Patients diagnosed with latent autoimmune diabetes of the adults (LADA) ( 9

Open access

Christian Høst, Anders Bojesen, Mogens Erlandsen, Kristian A Groth, Kurt Kristensen, Anne Grethe Jurik, Niels H Birkebæk, and Claus H Gravholt

hypergonadotropic hypogonadism ( 3 ). The incidence of the metabolic syndrome and insulin resistance is considerably higher in patients with KS ( 4 , 5 ), and epidemiological studies show an increased mortality due to diabetes as well as diseases of the

Open access

Jothydev Kesavadev, Pradeep Babu Sadasivan Pillai, Arun Shankar, Gopika Krishnan, and Sunitha Jothydev

, thiazolidinediones (TZDs), gliptins, GLP-1 analogs or gliflozins may be employed ( 21 ). The use of these traditional agents may be limited, however, because of several factors. Biguanides and TZDs improve the insulin resistance, but do not address the progressive