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Open access

Chunliang Yang, Junyi Li, Fei Sun, Haifeng Zhou, Jia Yang and Chao Yang

gluconeogenesis. Specifically, in the long run, metabolic disorders that are responsible for insulin resistance may also, in turn, damage the insulin-secreting capability of islet β cells through the accumulation of proinflammatory cytokines and toxic lipids ( 1

Open access

Alessandro Ciresi, Stefano Radellini, Valentina Guarnotta, Maria Grazia Mineo and Carla Giordano

). Blood samples were collected every 30 min for 2 h for glucose and insulin measurements. As surrogate estimates of insulin sensitivity we considered the homeostasis model assessment estimate of insulin resistance (Homa-IR) ( 19 ) and the insulin

Open access

Emanuela Zaharieva, Zdravko Kamenov, Tsvetelina Velikova, Adelina Tsakova, Yosif El-Darawish and Haruki Okamura

associated with a chronic low-grade inflammation ( 5 ) that has been implicated as a crucial factor for insulin resistance ( 6 ) and also beta-cell dysfunction ( 7 , 8 ). Patients diagnosed with latent autoimmune diabetes of the adults (LADA) ( 9

Open access

Christian Høst, Anders Bojesen, Mogens Erlandsen, Kristian A Groth, Kurt Kristensen, Anne Grethe Jurik, Niels H Birkebæk and Claus H Gravholt

hypergonadotropic hypogonadism ( 3 ). The incidence of the metabolic syndrome and insulin resistance is considerably higher in patients with KS ( 4 , 5 ), and epidemiological studies show an increased mortality due to diabetes as well as diseases of the

Open access

Jothydev Kesavadev, Pradeep Babu Sadasivan Pillai, Arun Shankar, Gopika Krishnan and Sunitha Jothydev

, thiazolidinediones (TZDs), gliptins, GLP-1 analogs or gliflozins may be employed ( 21 ). The use of these traditional agents may be limited, however, because of several factors. Biguanides and TZDs improve the insulin resistance, but do not address the progressive

Open access

Estíbaliz Castillero, Ana Isabel Martín, Maria Paz Nieto-Bona, Carmen Fernández-Galaz, María López-Menduiña, María Ángeles Villanúa and Asunción López-Calderón

most RA patients have increased basal plasma insulin levels and insulin resistance (24) , arthritic rats have lower serum insulin levels. In this sense, several factors account for the increased incidence of insulin resistance in RA that are not shared

Open access

Qiu-ming Yao, Bin Wang, Xiao-fei An, Jin-an Zhang and Liumei Ding

have been proposed to explain the association between testosterone and diabetes ( 50 , 51 ). Firstly, the key role of insulin resistance in the pathogenesis of T2DM has been well established. Previous studies have proven the inverse association between

Open access

Jukka Koffert, Henri Honka, Jarmo Teuho, Saila Kauhanen, Saija Hurme, Riitta Parkkola, Vesa Oikonen, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop and Pirjo Nuutila

.2–3.2) 2-h OGIS, oral glucose insulin sensitivity index; GIP, glucose-dependent insulinotrophic peptide; GLP-1, glucagon-like peptide 1; HbA1c, glycated hemoglobin; HOMA IR , homeostatic model assessment for insulin resistance; ISR, insulin secretion rate

Open access

Huguette S Brink, Aart Jan van der Lely and Joke van der Linden

incidence of GD is increasing in line with the global rise of obesity and type 2 diabetes mellitus (T2DM) ( 2 ). GD occurs when &-cells cannot compensate for the increased levels of insulin resistance ( 3 ). Insulin resistance and &-cell dysfunction are two

Open access

Jia Li, Yan Zhao, Caoxin Huang, Zheng Chen, Xiulin Shi, Long Li, Zhong Chen and Xuejun Li

Metabolite overview of the set of enriched biomarkers. Discussion NAFLD is considered a hepatic manifestation of metabolic syndrome and is strongly associated with insulin resistance ( 15 , 16 ). Our previous clinical trial contributed