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Xiuzhen Zhang, Dan Xu, Ping Xu, Shufen Yang, Qingmei Zhang, Yan Wu, and Fengyi Yuan

), cardiovascular disease (CVD) contributes to a two- to four-times higher death rate in patients with T1DM, compared with the general population ( 3 , 4 ). Diabetes Control and Complications Trials (DCCT) have exhibited that intensive insulin therapy attenuated

Open access

Taísa A R Vicente, Ívina E S Rocha, Roberto Salvatori, Carla R P Oliveira, Rossana M C Pereira, Anita H O Souza, Viviane C Campos, Elenilde G Santos, Rachel D C Araújo Diniz, Eugênia H O Valença, Carlos C Epitácio-Pereira, Mario C P Oliveira, Andrea Mari, and Manuel H Aguiar-Oliveira

Introduction GH regulates β-cell function (βCF) and insulin sensitivity (IS) both directly and via complex interactions with its principal mediator, insulin-like growth factor 1 (IGF1) (1) . While GH reduces IS, IGF1 increases it. The hyperglycemic

Open access

Patricia Iozzo and Maria Angela Guzzardi

exerted by obesity on cognitive dysfunction and vice versa. Both have been associated with morphological reductions in brain volume, relating to systemic dysmetabolism and insulin resistance and/or to the degree of cognitive impairment ( 21 , 22 , 23

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Xiuzhen Hou, Junfeng Zhang, Hehong Ma, Ming Li, and Pei Wang

Introduction Gestational diabetes mellitus (GDM) is primarily resulted from insulin resistance and glucose intolerance during pregnancy, affecting 7% of pregnant women globally ( 1 , 2 ). GDM causes higher risks of diabetes, obesity and

Open access

C L Bodinham, L Smith, E L Thomas, J D Bell, J R Swann, A Costabile, D Russell-Jones, A M Umpleby, and M D Robertson

. This was highlighted in a scientific advisory committee (SACN) statement on nutrition that stated, although cereal fiber intake has been associated with a reduced incidence of type 2 diabetes (T2DM) and metabolic risk factors such as insulin resistance

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Benjamin Paul Green, Javier Thomas Gonzalez, Kevin Thomas, Emma Stevenson, and Penny Louise Sheena Rumbold

) , glucagon (3) , insulin (4) , and leptin (5) , among others, represent several commonly measured metabolic variables documented as key effectors targeting energy intake and expenditure. Accurate quantification of these peptides is therefore essential when

Open access

Ling Hu, Ting Li, Xiao-Ling Yin, and Yi Zou

the increase in the incidence of TN is related to some components of MS ( 7 ). Researchers in the field have found that MS and insulin resistance are important factors associated with the increased incidence of nodular goiter and thyroid cancer ( 8

Open access

Dorte Glintborg, Magda Lambaa Altinok, Pernille Ravn, Kurt Bjerregaard Stage, Kurt Højlund, and Marianne Andersen

Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by insulin resistance and hyperandrogenism ( 1 ). Central obesity is closely associated with insulin resistance and low-grade inflammation ( 2 ) and

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Yael Sofer, Nava Nevo, Michal Vechoropoulos, Gabi Shefer, Etty Osher, Nathan Landis, Karen Tordjman, Geoffrey L Hammond, and Naftali Stern

of developing diabetes ( 7 ). High SHBG levels are apparently also associated with lower incidence of insulin resistance in men ( 10 ). Furthermore, cross-sectional studies in non-diabetic men and women have shown an inverse relationship between SHBG

Open access

Selina Mäkinen, Neeta Datta, Yen H Nguyen, Petro Kyrylenko, Markku Laakso, and Heikki A Koistinen

secondary ( 4 ) prevention of atherosclerotic events. However, data from several clinical studies have demonstrated that statin treatment increases the risk of type 2 diabetes ( 5 ). Statin use has been implicated with decreases in insulin secretion and