capacity of IAs and insulin; metformin may strengthen the action of free insulin and promote the dissociation of insulin immune complexes; and GLP-1 receptor agonists, as potent stimulators of insulin secretion, especially in combination with sulfonylurea
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Kaisa K Ivaska, Maikki K Heliövaara, Pertti Ebeling, Marco Bucci, Ville Huovinen, H Kalervo Väänänen, Pirjo Nuutila, and Heikki A Koistinen
Introduction Bone is increasingly recognized as an effector in energy metabolism via its interactions with other tissues (1, 2) . The role of bone-derived osteocalcin (OC) as a novel endocrine regulator of glucose and lipid metabolism was
Lin Ji, Huan-Tong Wu, Xiao-Yan Qin, and Rongfeng Lan
, Cpe KO Hyperproinsulinemia, β-cell stress Insulin, IAPP Naggert et al . 1995 , Marzban et al . 2005 Obesity Cpe fat / fat , Cpe KO Defects in energy balance regulation, satiety and nutrient partitioning CCK, neurotensin, GLP-1
Frederique Van de Velde, Marlies Bekaert, Anja Geerts, Anne Hoorens, Arsène-Hélène Batens, Samyah Shadid, Margriet Ouwens, Yves Van Nieuwenhove, and Bruno Lapauw
- or hyperthyroidism or a recent change in their medication. In total 16 subjects were excluded from the analysis; due to use of GLP-1 analogue ( n = 1) or insulin ( n = 7), refusing liver biopsy ( n = 1), no scored liver biopsy ( n = 4), no blood
Raluca Maria Furnica, Muhammad Muddaththir Dusoruth, Alexandre Persu, Damien Gruson, Michel Mourad, and Dominique Maiter
Petrák O Klímová J Mráz M Haluzíková D Doležalová RP Kratochvílová H Lacinová Z Novák K Michalsky D Waldauf P Pheochromocytoma with adrenergic biochemical phenotype shows decreased GLP-1 secretion and impaired glucose tolerance
Lei Lei, Yi-Hua Bai, Hong-Ying Jiang, Ting He, Meng Li, and Jia-Ping Wang
-cell-specific genes, such as insulin, Glut2, Pdx-1, Nkx6.1, GLP-1R, PC-1/3, and pyruvate carboxylase ( 36 ). Studies have shown that MAFA is an important regulator of glucose-stimulated insulin secretion ( 37 ), and it can drive insulin expression by binding to the
Angelica Amorim Amato, Hailey Brit Wheeler, and Bruce Blumberg
additional mechanisms that may mediate its obesogen effect. Such actions include impairment of glucagon-like peptide-1 (GLP-1) secretion, an important hormone regulating appetite, by the enteroendocrine cell line STC-1, ( 125 ) and/or androgen receptor action
T Grimmichova, M Haluzik, K Vondra, P Matucha, and M Hill
%, intensive insulin therapy 15.2%, diet 12.1%, combination of insulin with peroral antidiabetics (PAD) 7.6%, combination of PAD 6.1%, GLP-1 analogs 3%, gliptins 1.5%, and sulfonylureas 1.5% patients. Figure 1 Flow chart of the study. The
Maximilian Bielohuby, Martin Bidlingmaier, and Uwe Schwahn
.g. active GLP-1). Furthermore, it is important to check if further ‘additives’ are required to stabilize the analyte. One example for an analyte requiring a specific sampling protocol is acylated ghrelin, because here, acidification of the sample through
Jens F Rehfeld
-Bisset C Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length . American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2004 287 R
