Introduction Acromegaly is caused by overproduction of growth hormone (GH), in most cases by a pituitary adenoma. GH in turn induces production of insulin-like growth factor 1 (IGF1) ( 1 ). Both GH and IGF1 have numerous metabolic and trophic
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T L C Wolters, C D C C van der Heijden, N van Leeuwen, B T P Hijmans-Kersten, M G Netea, J W A Smit, D H J Thijssen, A R M M Hermus, N P Riksen, and R T Netea-Maier
Ana Podbregar, Tomaž Kocjan, Matej Rakuša, Peter Popović, Manca Garbajs, Katja Goricar, Andrej Janez, and Mojca Jensterle
MACE, particularly demonstrated in overweight and obese subjects. However, the magnitudes of observed progressions in growth or hormonal activity were clinically insignificant. Our long-term follow-up, therefore, clearly supports the general view that
Ivar Følling, Anna B Wennerstrøm, Tor J Eide, and Hilde Loge Nilsen
Introduction Phaeochromocytomas are tumours originating in the medulla of the adrenal gland. As the normal adrenal medulla, phaeochromocytomas mainly produce catecholamines but a few also produce ectopic hormones. Clinically, the most
J Chycki, A Zajac, M Michalczyk, A Maszczyk, and J Langfort
structure of study protocol. At each of the five time points (t0, t1, t2, t3, t4), venous blood samples were collected to determine growth hormone (GH) – t0, t3, t4 noradrenaline (NA) – t0, t3, insulin (I) – t0, t3, t4 cortisol (C) – t0, t3
Nadia Sabbah, Peter Wolf, Céline Piedvache, Séverine Trabado, Tristan Verdelet, Catherine Cornu, Jean-Claude Souberbielle, and Philippe Chanson
Introduction IGF-1 measurement is important for the diagnosis and management of patients with growth hormone (GH) deficiency or acromegaly as well as in their follow-up ( 1 , 2 ). We previously established normative data for six IGF-I assays
Jordyn Silverstein, Wesley Kidder, Susan Fisher, Thomas A Hope, Samantha Maisel, Dianna Ng, Jessica Van Ziffle, Chloe E Atreya, and Katherine Van Loon
with pregnancy have been the subject of extensive speculation, including the overexpression of pregnancy-related growth factors and human placental growth hormones and the immunosuppressive state of pregnancy. Other cancers have been shown to be
Silvia Ciancia, Vanessa Dubois, and Martine Cools
childhood, followed by a sharp acceleration from the onset of puberty onward, up to early adulthood. During puberty, the growth hormone (GH)/insulin-like growth factor (IGF)-1 axis and sex steroids become the main determinants of bone development, acting on
D A Dart, K Ashelford, and W G Jiang
a reduction in tumour cell growth. Often patients undergoing AR-antagonist therapy can become resistant to bicalutamide via many pathways – involving AR amplification, AR ligand-binding domain (LBD) mutations, cofactor/coregulator changes, and
Yiyan Wang, Yaoyao Dong, Yinghui Fang, Yao Lv, Qiqi Zhu, Xiaoheng Li, Qingquan Lian, and Ren-Shan Ge
DES induced an intrauterine growth restriction of pups in the placentas ( 6 ). However, the mechanism has not been fully elucidated. Figure 1 Chemical structure of cortisol and diethylstilbestrol. Glucocorticoid hormone is an inducing
Stine Linding Andersen and Stig Andersen
Introduction Hyperthyroidism is the clinical state that results from an excessive production of thyroid hormones in the thyroid gland ( 1 , 2 ). It is a signature of the disease that the incidence of the different subtypes of hyperthyroidism
