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Lauren E Henke, John D Pfeifer, Thomas J Baranski, Todd DeWees, and Perry W Grigsby

Introduction Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, accounting for 88% of thyroid carcinomas ( 1 , 2 ). Prognosis remains excellent and treatment, typically involving surgery followed by radioactive iodine

Open access

Jiwen Yang, Yayin Huang, Bohan Dong, and Yunhai Dai

in vitro . Introduction Thyroid cancer is a common endocrine malignant cancer ( 1 ). The survival of patients with thyroid cancer has improved with the combined therapy of surgery and radioactive iodine (RAI) therapy. However, the

Open access

Changjiao Yan, Meiling Huang, Xin Li, Ting Wang, and Rui Ling

. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial . Lancet 2014 384 . ( ) 24768112

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Wei Sun, Boyuan Zheng, Zhihong Wang, Wenwu Dong, Yuan Qin, and Hao Zhang

studies have reported benefits of PCLND in patients with cN0. For example, PCLDN can help to accurately diagnose tumor-node-metastasis (TNM) staging, help decide on the use of thyroid-stimulating hormone (TSH) suppression therapy or radioactive iodine (RAI

Open access

Katerina Saltiki, Elli Anagnostou, George Simeakis, Sofia Kouki, Anastasia Angelopoulou, Leda Sarika, Alexandra Papathoma, and Maria Alevizaki

metastases from PTC were present in 2/9 patients (the tall cell variant and one classical PTC). Three out of 9 patients received Radioactive Iodine therapy. All patients are in remission concerning PTC. Of the non-exon 8 carriers, only 1/48 (2.1%) had

Open access

Wei Li, Qing Huang, Danyang Sun, Guizhi Zhang, and Jian Tan

) ( 1 ). Through surgery and radioactive iodine ablation, most PTC patients have a good prognosis; however, a significant proportion of patients have persistent or recurrent disease and suffer from frequent recurrences or even distant metastases, leading

Open access

Bilal B Mughal, Jean-Baptiste Fini, and Barbara A Demeneix

chlorine and bromine. Interestingly, THs are the only complex halogenated (iodine) molecules produced by and necessary for vertebrate homeostasis, making TH physiology highly vulnerable to EDCs. Halogen-substituted phenolic moieties can mimic natural THs