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Samira M Sadowski, Emanuel Christ, Benoit Bédat, Attila Kollár, Wolfram Karenovics, Aurel Perren, Frédéric Triponez, and on behalf of the SwissNET registry

Cushing’s syndrome and the others had TC syndrome), with an additional patient with multiple endocrine neoplasia type 1 (MEN1). The mean interval between symptoms and diagnosis was 6 ± 9.9 months. Overall, the follow-up time was 30.2 ± 23.1 months, ranging

Open access

Veronica Kieffer, Kate Davies, Christine Gibson, Morag Middleton, Jean Munday, Shashana Shalet, Lisa Shepherd, and Phillip Yeoh

• Is able to explain Cushing's disease, Cushing's syndrome and cyclical Cushing's to a patient in simple terms, including signs and symptoms, investigations, and possible treatment options • Provides disease-specific education to the patient regarding

Open access

Ferdinand Roelfsema, Diana van Heemst, Ali Iranmanesh, Paul Takahashi, Rebecca Yang, and Johannes D Veldhuis

night. For diagnostic considerations, these subtle physiological adaptations are not relevant in diagnosing major endocrine disruptions such as Cushing’s disease, Cushing’s syndrome and primary and secondary adrenal failure. For these disorders

Open access

Weixi Wang, Rulai Han, Lei Ye, Jing Xie, Bei Tao, Fukang Sun, Ran Zhuo, Xi Chen, Xiaxing Deng, Cong Ye, Hongyan Zhao, and Shu Wang

found no sign of Cushing’s syndrome. Evaluation of adrenal hormone revealed loss of cortisol rhythm (8:00–16:00–24:00 25.81–25.77–23.82 μg/dL) and elevated urinary free cortisol (UFC) (1287 μg/24 h, normal 21–111 μg/24 h). Overnight dexamethasone

Open access

Efstratios Kardalas, Stavroula A Paschou, Panagiotis Anagnostis, Giovanna Muscogiuri, Gerasimos Siasos, and Andromachi Vryonidou

catecholamine excess or MRI of pituitary gland (in order to exclude Cushing’s disease) are useful in establishing the cause of hypokalemia. Moreover, an abdominal CT scan should be performed if clinical and laboratory features of VIPoma are present, such as

Open access

Kathrin R Frey, Tina Kienitz, Julia Schulz, Manfred Ventz, Kathrin Zopf, and Marcus Quinkler

adrenalectomized for Cushing’s disease: comparison of various glucocorticoids . Journal of Clinical Endocrinology and Metabolism 1982 55 551 – 559 . ( ) 10.1210/jcem-55-3-551 41 Frara S Chiloiro S Porcelli T

Open access

Zeeshan Javed, Maria Papageorgiou, Leigh A Madden, Alan S Rigby, Eric S Kilpatrick, Stephen L Atkin, and Thozhukat Sathyapalan

deficiency, hyperprolactinaemia, Cushing’s disease and androgen-secreting tumours, pregnancy or intention to become pregnant, breastfeeding, documented use of oral hormonal contraceptives and hormone-releasing implants, metformin or other insulin

Open access

Jung Soo Lim, Seung-Eun Lee, Jung Hee Kim, Jae Hyeon Kim, and The Korean Adrenal Gland and Endocrine Hypertension Study Group, Korean Endocrine Society

.13–6.71, P  = 0.025) for ACC-specific death but not for all-cause mortality. The poorer prognosis of cortisol-secreting tumors might be related to comorbidity with Cushing’s syndrome and its possible immunosuppressive effects that may promote tumor

Open access

Sirazum Choudhury, Tricia Tan, Katharine Lazarus, and Karim Meeran

Introduction Between 1928 and 1938, patients with Addison’s disease had a 100% 5-year mortality ( 1 ). With the availability of glucocorticoid replacement therapy, initially with animal adrenocortical extract and later synthetic 11

Open access

David J F Smith, Hemanth Prabhudev, Sirazum Choudhury, and Karim Meeran

glucocorticoid dosing. The discovery of glucocorticoids in the 1940s converted conditions such as Addison’s disease and many autoimmune diseases into conditions that were no longer rapidly fatal ( 21 ). Doctors have tended to over-prescribe steroids to prevent