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Hugo R Ramos, Andreas L Birkenfeld, and Adolfo J de Bold

: hypertriglyceridemia (1.7 mmol/l), low HDL cholesterol (<1.03 mmol/l in men and <1.29 mmol/l in women), hyperglycemia (>11.1 mmol/l or a diagnosis of diabetes), hypertension (≥130/85 mmHg) or medication for high blood pressure (34, 35) . In a 12-year follow-up of 61

Open access

Sayaka Kawano, Yukiko Kawagoe, Kenji Kuwasako, Satoshi Shimamoto, Koji Igarashi, Mariko Tokashiki, Kazuo Kitamura, and Johji Kato

protection, and alleviation of insulin resistance (4, 5, 6, 7) . On the other hand, AM was shown to circulate in human blood, and its plasma levels are elevated in diseases such as hypertension, heart failure, and sepsis (2, 8) . Plasma AM levels have also

Open access

Marianne Aa Grytaas, Kjersti Sellevåg, Hrafnkell B Thordarson, Eystein S Husebye, Kristian Løvås, and Terje H Larsen

Introduction Primary aldosteronism (PA) has been recognized as the most common cause of secondary hypertension (HT), with estimated prevalence of 5–12% of all hypertensive subjects ( 1 , 2 ). In patients with refractory HT, PA may be present

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Kirsty G Pringle, Sarah J Delforce, Yu Wang, Katie A Ashton, Anthony Proietto, Geoffrey Otton, C Caroline Blackwell, Rodney J Scott, and Eugenie R Lumbers

.wcrf.org/int/cancer-facts-figures/data-specific-cancers/endometrial-cancer-cancer-lining-womb-statistics ), accessed on 30 January 2013), and potential risk factors for this disease include obesity, hypertension, diabetes and hyperoestrogenism, all of which are linked to activation of the renin–angiotensin system (RAS) ( 1 , 2 ). The RAS is an important

Open access

Satoshi Higuchi, Hideki Ota, Yuta Tezuka, Kazumasa Seiji, Hidenobu Takagi, Jongmin Lee, Yi-Wei Lee, Kei Omata, Yoshikiyo Ono, Ryo Morimoto, Masataka Kudo, Fumitoshi Satoh, and Kei Takase

Introduction Primary aldosteronism (PA) is one of the most frequent forms of secondary hypertension with an estimated prevalence of approximately 11% in hypertensive populations ( 1 , 2 ). Some patients with PA suffer from refractory

Open access

Rongpeng Gong, Gang Luo, Mingxiang Wang, Lingbo Ma, Shengnan Sun, and Xiaoxing Wei

smoking, alcohol, hyperlipidemia, and hypertension, have been identified as risk factors for developing IR. Since these causes are common in modern life, we expect IR to become increasingly common in the general population unless public awareness is

Open access

Tsuneo Ogawa and Adolfo J de Bold

is seen in chronic arterial hypertension and chronic congestive heart failure and is accompanied by the ventricular re-expression of the cardiac foetal gene programme, which includes the re-expression of both ANF and BNP (28, 32) . The main source of

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Maria Angela D'amico, Barbara Ghinassi, Pascal Izzicupo, Lamberto Manzoli, and A Di Baldassarre

. Knockout mice for CgA expression are viable and fertile and do not show developmental abnormalities (9) , even if they develop a severe hypertension (14) . Their neural and endocrine functions are not grossly impaired and adrenal glands present regular

Open access

Chunliang Yang, Junyi Li, Fei Sun, Haifeng Zhou, Jia Yang, and Chao Yang

fundamental biological activities, such as ion channel opening, metabolite transport, hormone release and cell survival ( 4 ). Excessive expression and activity of SGK1 is implicated in the progression of diverse disorders, including hypertension, obesity

Open access

Jingci Chen, Yan Wu, Pengyan Wang, Huanwen Wu, Anli Tong, and Xiaoyan Chang

Hypertension; tachycardia 29.37; 6.80 ; 403.78 Adrenal 2.5 70 30 <1 T1N0M0 stage I NA 2 62/M Hypertension 32.5; 6.63 ; 294.92 Adrenal 14 90 10 1 T2N0M0 stage II NA 3 43/M Tachycardia 15.69; 4.08; 174