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M Jensterle, A Podbregar, K Goricar, N Gregoric, and A Janez

) should be recommended as the first-line approach ( 2 , 3 ), yet in clinical practice LSM often fails. On the other hand, testosterone replacement therapy (TRT) appears to improve body composition and glycometabolic profile without clearly affecting

Open access

Thomas Reinehr, Alexandra Kulle, Juliane Rothermel, Caroline Knop-Schmenn, Nina Lass, Christina Bosse, and Paul-Martin Holterhus

, 21-deoxycorticosterone, deoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, cortisone, androstenedione, testosterone, dehydroepiandrostenedione sulfate (DHEA-S), estrone (E1), estradiol (E2), luteinizing hormone (LH), follicle

Open access

Tristan Avril, Quentin Hennocq, Anne-Sophie Lambert, Juliane Leger, Dominique Simon, Laetitia Martinerie, and Claire Bouvattier

cells, and perhaps, by extension, for future fertility ( 3 , 4 , 5 , 6 ). Anti-Müllerian hormone (AMH) and Inhibin B are reliable biomarkers reflecting Sertoli cells function, while testosterone is an index of Leydig cell activation. Boys with CHH

Open access

Sandra R Dahl, Ingrid Nermoen, Ingeborg Brønstad, Eystein S Husebye, Kristian Løvås, and Per M Thorsby

(CAH due to steroid 21-hydroxylase deficiency) consistently timed hormone measurements relative to medication schedule and time of day is recommended ( 1 ). Drug fasting morning values of androstenedione and testosterone should be in the normal range

Open access

Henrik H Thomsen, Holger J Møller, Christian Trolle, Kristian A Groth, Anne Skakkebæk, Anders Bojesen, Christian Høst, and Claus H Gravholt

by the low levels of sex hormones (12, 13) , 17β-estradiol (E 2 ) and testosterone, that are known to modulate the inflammatory state of macrophages (21, 22) . An experiment of testosterone and E 2 cultured Hofbauer cells (fetal macrophages) found

Open access

Liza Haqq, James McFarlane, Gudrun Dieberg, and Neil Smart

resistance and hyperinsulinaemia, but these two features are also present in lean women with PCOS (5, 6) . Hormonal manifestations include elevated levels of androgens (testosterone, DHEA and androstenedione), oestrogens and prolactin. Occasionally, thyroid

Open access

Paal Methlie, Steinar Hustad, Ralf Kellman, Bjørg Almås, Martina M Erichsen, Eystein S Husebye, and Kristian Løvås

, 11-deoxycortisol (11DOC), testosterone, androstenedione, 17α-hydroxyprogesterone (17OHP) and progesterone were obtained from Steraloids, Inc. (Newport, RI, USA), and DXM was obtained from Alfa Aesar (Ward Hill, MA, USA). The deuterated internal

Open access

M Boering, P R van Dijk, S J J Logtenberg, K H Groenier, B H R Wolffenbuttel, R O B Gans, N Kleefstra, and H J G Bilo

gonadotropins and sex steroids, concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, and 17-β-estradiol were also assessed. Subjects, materials and methods Study design This study is a post hoc analysis of a

Open access

Herjan J T Coelingh Bennink, Jan Krijgh, Jan F M Egberts, Maria Slootweg, Harm H E van Melick, Erik P M Roos, Diederik M Somford, Yvette Zimmerman, Iman J Schultz, Noel W Clarke, R Jeroen A van Moorselaar, and Frans M J Debruyne

in combination with androgen receptor signaling inhibitors, radiotherapy and/or chemotherapy ( 6 ). The purpose of ADT is to suppress the major driver of PCa tumor growth testosterone as much as possible ( 7 ). The suppression of testosterone causes

Open access

Katarzyna Wyskida, Grzegorz Franik, Tomasz Wikarek, Aleksander Owczarek, Alham Delroba, Jerzy Chudek, Jerzy Sikora, and Magdalena Olszanecka-Glinianowicz

samples were frozen and stored at −70°C. Laboratory procedures Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol (E 2 ), total testosterone, free testosterone, androstendione, DHEA-S and SHBG were