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Cecília Cristelo, Alexandra Machado, Bruno Sarmento, and Francisco Miguel Gama

onset of type 1 diabetes, showed an increased expression of cathelicidin in the epithelial lining of the small intestine and an increase in the relative abundance of M2-macrophages ( 100 ). Sun et al. ( 99 ) also demonstrated that CRAMP expression in

Open access

Frederic Schrøder Arendrup, Severine Mazaud-Guittot, Bernard Jégou, and David Møbjerg Kristensen

extent in the kidney and intestines ( 5 ). After a therapeutic dose, APAP is mostly converted to pharmacologically inactive glucuronide (APAP-gluc, 52–57% of urinary metabolites) and sulfate (APAP sulfate, 30–44%) conjugates by phase II biotransformation

Open access

Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant, and Agnès Linglart

, 24 ). About 40% of mitotane is absorbed through the intestine, and then binds to lipophilic proteins and is metabolized in the liver. It accumulates in adipose tissue from where it can be released for weeks to months ( 24 , 25 ), making it difficult

Open access

Justyna Modrzynska, Christine F Klein, Kasper Iversen, Henning Bundgaard, Bolette Hartmann, Maike Mose, Nikolaj Rittig, Niels Møller, Jens J Holst, and Nicolai J Wewer Albrechtsen

Introduction Glucagon and glucagon-like peptide-1 (GLP-1) are processed from the same precursor, proglucagon ( Fig. 1 ), and have opposite effects on glucose homeostasis ( 1 , 2 , 3 ). In the intestine, proglucagon is cleaved by prohormone

Open access

Tiina Vesterinen, Teijo Kuopio, Maarit Ahtiainen, Aija Knuuttila, Harri Mustonen, Kaisa Salmenkivi, Johanna Arola, and Caj Haglund

02628067) of patients with well- and moderately differentiated neuroendocrine tumor of the lung, appendix, small intestine, colon, rectum or pancreas ( n  = 107) ( 32 ). In this study, pembrolizumab showed antitumor activity with an overall response rate of

Open access

Chenghao Piao, Xiaojie Wang, Shiqiao Peng, Xinyu Guo, Hui Zhao, Li He, Yan Zeng, Fan Zhang, Kewen Zhu, and Yiwei Wang

and intestine of inflammatory bowel disease (IBD) patients ( 16 ). Moreover, IL-34 can be detected in adipose tissues, and the concentration of IL-34 is markedly upregulated in obesity patients and highly related to insulin resistance ( 17 ). The

Open access

Sara Storvall, Helena Leijon, Eeva Ryhänen, Johanna Louhimo, Caj Haglund, Camilla Schalin-Jäntti, and Johanna Arola

well as pheochromocytomas and paragangliomas (antibodies for SST 2 -SST 4 ( 34 )). We stained control tissue (pancreas and small intestine) to serve as a test for the functionality of the staining protocol as well as internal negative control. The

Open access

Bharat Kumar, Madhukar Mittal, Maya Gopalakrishnan, Mahendra K Garg, and Sanjeev Misra

expressed on the pancreatic islets, leading to islet destruction and acute diabetes ( 50 , 51 ). ACE2, which was previously thought to be restricted to the lungs, is expressed in many human tissues including the intestines, kidneys, myocardium, vasculature

Open access

Yao Su, Li Chen, Dong-Yao Zhang, Xu-Pei Gan, Yan-Nan Cao, De-Cui Cheng, Wen-Yu Liu, Fei-Fei Li, Xian-Ming Xu, and Hong-Kun Wang

levels of Bacteroidetes were positively correlated with the occurrence of diabetes ( 11 ). The possible mechanisms of intestinal flora imbalance leading to obesity and diabetes are: ( 1 ) changes to Firmicutes and Bacteroidetes in the intestine

Open access

Athanasios D Anastasilakis, Marina Tsoli, Gregory Kaltsas, and Polyzois Makras

disease ( 4 ). Most frequently affected organs include the bones, lungs, pituitary gland and skin while the lymph nodes, liver, spleen, intestine and central nervous system are less frequently involved. Clinical manifestations are various according to the