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Tsuneo Ogawa and Adolfo J de Bold

ANF and its sensitivity to PTX (46) . An involvement of glucagon-like peptide-1 (GLP1) has recently been implicated in the regulation of ANF secretion from the heart. GLP1 is one of the incretin hormones secreted from endocrine cells located in the

Open access

Zhandong Lei, Yunfei Chen, Jin Wang, Yan Zhang, Wenjuan Shi, Xuejiao Wang, Dehai Xing, Dongxue Li, and Xiangying Jiao

then diluted 1:4 and stored at −80°C until assay. For Mouse Bio-Plex Pro Assays, 25 μL of serum per sample was analyzed. The concentration levels of insulin, glucagon, glucagon-like peptide-1 (GLP1) and Leptin were measured using the Mouse Diabetes

Open access

Monia Cito, Silvia Pellegrini, Lorenzo Piemonti, and Valeria Sordi

diabetic stress conditions, glucagon-producing α cells are important to maintain β cell health and function through GLP-1 secretion ( 40 , 41 ) suggesting an α-cell-mediated adaptive response to β-cell stress and injury. Collombat and colleagues

Open access

Mônica R Gadelha, Feng Gu, Marcello D Bronstein, Thierry C Brue, Maria Fleseriu, Ilan Shimon, Aart J van der Lely, Shoba Ravichandran, Albert Kandra, Alberto M Pedroncelli, and Annamaria A L Colao

greater degree than glucagon, which results in increased glucose levels ( 19 ). Indeed, pasireotide has been shown to reduce secretion of insulin, glucagon, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide in healthy volunteers

Open access

Clemens Kamrath, Alexander Eckert, Birgit Rami-Merhar, Sebastian Kummer, Martin Wabitsch, Katharina Laubner, Florian Kopp, Silvia Müther, Steffen Mühldorfer, and Reinhard W Holl

<0.001 ns  Glinides 0.1 2.8 4.0 2.4 <0.001 ns <0.001 ns  Sulfonylureas 0.4 9.6 4.0 2.4 ns ns ns ns  GLP-1 analogs 0.1 3.9 12.0 2.4 <0.001 ns 0.005 ns  DPP4 inhibitors 0.4 17

Open access

Hui-qing Yuan, Jia-xi Miao, Jia-ping Xu, Su-xiang Zhu, Feng Xu, Xiao-hua Wang, Chun-hua Wang, Chao Yu, Xue-qin Wang, Jian-bin Su, and Dong-mei Zhang

peptidase-4 inhibitors (DPP-4Is), SGLT-2Is and glucagon-like peptide-1 receptor agonists (GLP-1RAs). Fasting venous blood samples were taken to detect biochemical indices, such as serum CysC levels, hepatic function index, creatinine, uric acid (UA), lipid

Open access

Florian W Kiefer

activity. However, the effects were not sufficient to induce a loss of body weight or fat mass ( 59 ). In contrast, treatment with the antidiabetic agent liraglutide, which acts as an agonist at the glucagon-like peptide-1 (GLP-1) receptor results in

Open access

Ruixin Hu, Yanting Yuan, Chaolong Liu, Ji Zhou, Lixia Ji, and Guohui Jiang

/11 signaling pathway ( 11 , 12 ), (ii) In endocrine L cells of colon, FFAR2 mediates the secretion of GLP-1 by coupling with the ligand SCFAs, which in turn promotes the proliferation of functional islet β-cells mass ( 13 , 14 ). Besides, SCFAs can

Open access

David Koeckerling, Jeremy W Tomlinson, and Jeremy F Cobbold

greater, more sustained weight loss than other procedures with almost immediate, weight-independent effects on glycaemic control, insulin sensitivity and GLP-1 secretion ( 45 , 69 ). Sleeve gastrectomy produces less marked, but comparable, effects to Roux

Open access

J Van Schaik, M Burghard, M H Lequin, E A van Maren, A M van Dijk, T Takken, L B Rehorst-Kleinlugtenbelt, B Bakker, L Meijer, E W Hoving, M Fiocco, A Y N Schouten-van Meeteren, W J E Tissing, and H M van Santen

GLP-1. Additionally, the disruption of autonomic function damages the biologic clock and therefore the circadian activity ( 13 ). Next to energy balance, the hypothalamus also plays an essential role in the body’s temperature regulation, thirst