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Sarah Ying Tse Tan, Hong Chang Tan, Ling Zhu, Lih Ming Loh, Dawn Shao Ting Lim, Du Soon Swee, Yoke Ling Chan, Huee Boon Lim, Shiau Lee Ling, En Jun Ou, Wynn Ee Teo, Xiao Ping Zhang, Hui Fen Goh, and Peng Chin Kek

, the adrenocorticotrophic hormone (ACTH) stimulation test (AST) is the most commonly used ( 3 ). During the AST, 250 µg of synthetic ACTH was administered intravenously or intramuscularly, and serum cortisol is drawn at baseline, 30 min, and 60 min

Open access

Kathrin Zopf, Kathrin R Frey, Tina Kienitz, Manfred Ventz, Britta Bauer, and Marcus Quinkler

of 37.7 months. Second, it is still unknown how the Bcl I polymorphism exerts its effects. After administration of dexamethasone, serum cortisol levels were lower in G-allele carriers of the BclI polymorphism, pointing to a greater glucocorticoid

Open access

Marcus Imamovic, Nils Bäcklund, Staffan Lundstedt, Göran Brattsand, Elisabeth Aardal, Tommy Olsson, and Per Dahlqvist

Introduction Timely diagnosis of endogenous Cushing's syndrome (CS) is important to reduce morbidity and mortality ( 1 , 2 , 3 ). Late-night salivary cortisol (LNSC) is an important screening instrument for CS with high sensitivity and

Open access

Karim Gariani, Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, and François R Jornayvaz

hypertension, might be linked with an excess of glucocorticoid secretion ( 2 , 3 , 4 ). Patients with metabolic syndrome and concomitantly higher fasting cortisol have been related with more prevalent central obesity and hypertension, a higher triglycerides

Open access

Fahim Ebrahimi, Sandrine A Urwyler, Philipp Schuetz, Beat Mueller, Luca Bernasconi, Peter Neyer, Marc Y Donath, and Mirjam Christ-Crain

adrenocorticotropin hormone (ACTH)-producing cells in the pituitary gland ( 7 ) and third in the adrenal glands with direct stimulatory effect on cortisol production ( 11 ). Therapeutic interventions aimed at counteracting inflammatory activation have proven

Open access

Britt J van Keulen, Conor V Dolan, Bibian van der Voorn, Ruth Andrew, Brian R Walker, Hilleke Hulshoff Pol, Dorret I Boomsma, Joost Rotteveel, and Martijn J J Finken

cortisol levels. Compared to girls, boys, up to age 8, had higher salivary cortisol levels and lower levels beyond this age ( 11 ). The timing of this change suggests that sex steroids influence the HPA axis. Surprisingly, to the best of our knowledge

Open access

Fiona Broughton Pipkin, Hiten D Mistry, Chandrima Roy, Bernhard Dick, Jason Waugh, Rebecca Chikhi, Lesia O Kurlak, and Markus G Mohaupt

feedback control of glucocorticoid maintenance and an association with metabolic syndrome (10, 11) . Little is known about steroid hormone availability and metabolism during the early postpartum period in infants. Fetal exposure to maternal cortisol is

Open access

Ida Staby, Jesper Krogh, Marianne Klose, Jonas Baekdal, Ulla Feldt-Rasmussen, Lars Poulsgaard, Jacob Bertram Springborg, and Mikkel Andreassen

avoid an adrenal crisis. There are different ways to examine the adrenal axis pre-surgery, for example, the measurement of random spot plasma cortisol, measurement of cortisol after adrenocorticotropic hormone (ACTH) stimulation (Synacthen ® -test) or

Open access

Kristin Viste, Marianne A Grytaas, Melissa D Jørstad, Dag E Jøssang, Eivind N Høyden, Solveig S Fotland, Dag K Jensen, Kristian Løvås, Hrafnkell Thordarson, Bjørg Almås, and Gunnar Mellgren

, adrenal computed tomography (CT) has sensitivity and specificity at 78% and 72–75% respectively (7, 11) . During AVS, blood samples are drawn from the right and left adrenal veins as well as a peripheral vein. The ratio between cortisol measured in the

Open access

Trevor Lewis, Eva Zeisig, and Jamie E Gaida

). As well as causing dyslipidemia via increased visceral adiposity ( 20 , 23 ), cortisol also affects lipid processing pathways in the liver ( 48 ). These include enhanced lipolysis, altered free fatty acid processing, and hepatic fat accumulation ( 48