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Siphiwe N Dlamini, Zané Lombard, Lisa K Micklesfield, Nigel Crowther, Shane A Norris, Tracy Snyman, Andrew A Crawford, Brian R Walker, and Julia H Goedecke

from study sample 1. The selection of the participants for the present study was primarily based on the availability of serum samples for glucocorticoid determination. Participants who were pregnant or using corticosteroid medication were excluded

Open access

Robert I Menzies, Xin Zhao, Linda J Mullins, John J Mullins, Carolynn Cairns, Nicola Wrobel, Donald R Dunbar, Matthew A Bailey, and Christopher J Kenyon

corticosteroid release ( 1 , 2 ). Closer analysis of acute responses has demonstrated that activation of melanocortin receptors trigger cyclic AMP synthesis, leading to the synthesis of StaR, which promotes the uptake of cholesterol into mitochondria ( 3 , 4

Open access

Carla Scaroni, Nora M Albiger, Serena Palmieri, Davide Iacuaniello, Chiara Graziadio, Luca Damiani, Marialuisa Zilio, Antonio Stigliano, Annamaria Colao, Rosario Pivonello, and the Altogether to Beat Cushing’s Syndrome (ABC) study group

cortisol secretion over a 24-h period. It measures the cortisol that is not bound to corticosteroid-binding globulin (CBG), which is filtered by the kidney unchanged. A falsely low UFC can occur when creatinine clearance falls less than 60 mL/min ( 3 ). It

Open access

Helga Schultz, Svend Aage Engelholm, Eva Harder, Ulrik Pedersen-Bjergaard, and Peter Lommer Kristensen

and other variables (explanatory variables) in univariate and multivariate logistic regression models with corticosteroid-induced insulin-treated diabetes as dependent variable. Established risk factors for type 2 diabetes (sex, age, HbA1c, BMI, having

Open access

Hershel Raff and Hariprasad Trivedi

filtration rate >70 ml/min per 1.73 m 2 . The primary outcome of the study was the comparison of the circadian rhythm of plasma and salivary cortisol. Exclusions included diabetes mellitus, subjects on oral corticosteroid preparations, pregnant women (serum

Open access

Ziting Liang, Mengge Yang, Changjuan Xu, Rong Zeng, and Liang Dong

increased risk of diabetes mellitus (DM) due to the sedentary lifestyle and adiposity of COPD patients, the inflammatory processes ( 2 ), and the treatment adverse effects associated with the use of high-dose corticosteroids ( 3 ). On the other hand

Open access

Jaafar Jaafar, Eugenio Fernandez, Heba Alwan, and Jacques Philippe

corticosteroids) Nivolumab Hypothyroidism 2–3 month (range 1 day–16.6 month) Frequently stay in hypothyroidism with long-term THR Pembrolizumab Hyperthyroidism 1.4 month (range: 1 day to ~22 month) Three-fourths of affected patients 2

Open access

Arno Téblick, Lies Langouche, and Greet Van den Berghe

referred to as ‘relative adrenal insufficiency’, this state is nowadays labeled ‘critical illness-related corticosteroid insufficiency’ (CIRCI). In contrast to the occurrence of absolute adrenal failure in critically ill patients, neither a clear definition

Open access

Paraskevi Kazakou, Stavroula A Paschou, Theodora Psaltopoulou, Maria Gavriatopoulou, Eleni Korompoki, Katerina Stefanaki, Fotini Kanouta, Georgia N Kassi, Meletios-Athanasios Dimopoulos, and Asimina Mitrakou

secretion (11, 69) Drugs (corticosteroids, antivirals) (11, 34) Cahexia, muscle weakness, rhabdomyolysis lead to decreased insulin sensitivity (35, 36, 37) DPP4 potential SARS-CoV-2 receptor (70, 71, 72, 73) Hypothalamus and pituitary Possible

Open access

Jakub Supronik, Małgorzata Szelachowska, Adam Kretowski, and Katarzyna Siewko

patients (12 in the placebo arm and 13 in the RTX arm), 21 completed the primary endpoint of 24 weeks and 19/21 completed the 52-week observation. Both groups were similar at baseline with regard to age, sex, smoking status, prior corticosteroid treatment