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Muhammad Fahad Arshad, Ahmed Iqbal, James Weeks, Ines Fonseca, Alia Munir, and William Bennet

the risk of adverse neurological events from rapid bidirectional fluxes in serum sodium. At variance with ESE guidelines, our data indicate that an additional strategy that may prevent or slow down overcorrection, and reduce the need for re

Open access

Fernanda A Correa, Ericka B Trarbach, Cintia Tusset, Ana Claudia Latronico, Luciana R Montenegro, Luciani R Carvalho, Marcela M Franca, Aline P Otto, Everlayny F Costalonga, Vinicius N Brito, Ana Paula Abreu, Mirian Y Nishi, Alexander A L Jorge, Ivo J P Arnhold, Yisrael Sidis, Nelly Pitteloud, and Berenice B Mendonca

is located within the last intracellular loop, and results of functional analyses revealed normal transcription activity in an Erg-Luc assay but decreased calcium mobilization activity (72% of WT) in an aequorin-based Ca 2+ flux assay. Its expression

Open access

Selina Mäkinen, Neeta Datta, Yen H Nguyen, Petro Kyrylenko, Markku Laakso, and Heikki A Koistinen

-mediated. As glucose uptake was increased and glucose oxidation markedly diminished, glucose fluxes were directed towards non-oxidative glucose disposal in muscle cells treated with lactone-form simvastatin. The increase in glucose incorporation into glycogen

Open access

J Chycki, A Zajac, M Michalczyk, A Maszczyk, and J Langfort

operates in a different manner in this group of subjects, and may be attributed to their dietary status, which was characterized by a significantly higher energy intake from fats ( Table 1 ). The driving force of the FFA flux from vascular space to muscle

Open access

Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou, and Zubing Mei

Honkanen-Scott M Shaw JAM Lovat PE Arden C. Glucagon-like peptide 1 protects pancreatic beta-cells from death by increasing autophagic flux and restoring lysosomal function . Diabetes 2017 66 1272 – 1285 . ( ) 10

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Karim Gariani and François R Jornayvaz

lipogenesis and adipose tissue lipolysis, leading to an increased flux of fatty acids to the liver ( 30 ). Insulin resistance will also lead to adipose tissue dysfunction inducing secretion of inflammatory cytokines ( 31 ). Intrahepatic accumulation of fatty

Open access

Huma Qamar, Nandita Perumal, Eszter Papp, Alison D Gernand, Abdullah Al Mahmud, and Daniel E Roth

the placenta ( 14 , 15 ). As such, maternal PTH likely regulates bone growth through transplacental calcium flux or other indirect mechanisms. During pregnancy, the increased demand for calcium to support fetal growth is met by increasing maternal

Open access

Katrine M Lauritsen, Jens Hohwü Voigt, Steen Bønløkke Pedersen, Troels K Hansen, Niels Møller, Niels Jessen, Lars C Gormsen, and Esben Søndergaard

effects of SGLT2 inhibition on both substrate fluxes, enzyme activity, protein and gene expression in adipose tissue. However, the study also has limitations. The study was powered according to the primary endpoint which was myocardial FFA oxidation. The

Open access

Peter Wolf, Yvonne Winhofer, Martin Krššák, and Michael Krebs

rather small, compared to that in skeletal muscle ( 10 ), indicating that intracellular lipid stores might play more important role in states of increased energy demands. As reported by Randle and coworkers in the early 1960s, fluxes of FA and glucose

Open access

Chanyang Kim and Seungjoon Park

main regulators in neuroprotection in PD. As one of the gatekeepers of the Krebs cycle, CS plays an important role in regulating the energy flux and metabolic rate of the cell. Impaired activity of CS is known to interfere mitochondrial function and