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Ling Shan, Yingying Zhou, Shiqiao Peng, Xinyi Wang, Zhongyan Shan, and Weiping Teng

Introduction Subclinical hypothyroidism (SCH), characterized by elevated levels of thyroid-stimulating hormone (TSH) with total thyroxine (TT4) within the normal reference range, is the most common type of thyroid disorder in pregnancy ( 1

Open access

Kinnaree Sorapipatcharoen, Thipwimol Tim-Aroon, Pat Mahachoklertwattana, Wasun Chantratita, Nareenart Iemwimangsa, Insee Sensorn, Bhakbhoom Panthan, Poramate Jiaranai, Saisuda Noojarern, Patcharin Khlairit, Sarunyu Pongratanakul, Chittiwat Suprasongsin, Manassawee Korwutthikulrangsri, Chutintorn Sriphrapradang, and Preamrudee Poomthavorn

Introduction Congenital primary hypothyroidism (CH) is classified into thyroid dysgenesis (TD) and thyroid dyshormonogenesis (TDH) ( 1 ). TDH has increasingly been reported while the incidence of TD has remained stable ( 2 , 3 ). Genetic

Open access

Fan Zhang, Jian Chen, Xinyue Lin, Shiqiao Peng, Xiaohui Yu, Zhongyan Shan, and Weiping Teng

Introduction Thyroid hormones (THs) are vital for fetal neurodevelopment. The prevalence of subclinical hypothyroidism (SCH) in the general population is 4–10% and can reach 5% in pregnant women. Haddow et al . investigated the intelligence

Open access

Nella Augusta Greggio, Elisa Rossi, Silvia Calabria, Alice Meneghin, Joaquin Gutierrez de Rubalcava, Carlo Piccinni, and Antonella Pedrini

Introduction Subclinical hypothyroidism (SH) is a biochemical condition defined as serum thyroid-stimulating hormone (TSH) exceeding the limit of its reference range by age, while the concentration of serum free thyroxin (FT4) remains within

Open access

Ulla Schmidt, Birte Nygaard, Ebbe Winther Jensen, Jan Kvetny, Anne Jarløv, and Jens Faber

healthy euthyroid subjects, ∼20% of T 3 is derived from thyroidal secretion and the remaining from local production (2) . By contrast, hypothyroid subjects substituted with levothyroxine ( l -T 4 ) monotherapy demonstrated higher plasma T 4 /T 3 ratio

Open access

Chunyun Fu, Shiyu Luo, Yingfeng Li, Qifei Li, Xuehua Hu, Mengting Li, Yue Zhang, Jiasun Su, Xuyun Hu, Yun Chen, Jin Wang, Bobo Xie, Jingsi Luo, Xin Fan, Shaoke Chen, and Yiping Shen

Introduction Congenital hypothyroidism (CH) is one of the most common causes of intellectual disability and growth retardation with worldwide incidence ranging from 1:2000 to 1:4000 newborns ( 1 , 2 , 3 ). Newborn screening allows for early

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Sahar Hossam El Hini, Yehia Zakaria Mahmoud, Ahmed Abdelfadel Saedii, Sayed Shehata Mahmoud, Mohamed Ahmed Amin, Shereen Riad Mahmoud, and Ragaa Abdelshaheed Matta

Introduction Overt hypothyroidism (OH) and subclinical hypothyroidism (SCH) are characterized by the coexistence of traditional cardiovascular disease risk factors, insulin resistance (IR), elevated inflammatory markers, altered hemodynamic

Open access

Carmen Sydlik, Ilja Dubinski, Susanne Bechtold, and Heinrich Schmidt

Thyroid stimulating hormone is generally regarded as a standard parameter for evaluation of thyroid function. However, relying on this hormone alone can be misleading. Therefore, thyroxine/free-thyroxine levels are used in patients with levothyroxine substitution for adjustment of therapy. Even with normal values for free-thyroxine, decreased values for the free- triiodothyronine/ free-thyroxine ratio have already been described in adults. In this study, the free-triiodothyronine/ free-thyroxine ratio of 25 children with congenital hypothyroidism was compared with 470 healthy children seen for other reasons then thyroid dysfunction. Mean free thyroxine in congenital hypothyroidism was just below the upper limit of normal and significantly higher than in control group. Mean values for free triiodothyronine showed no significant difference between the two groups. The mean value for free triiodothyronine/ free thyroxine ratio in control group was 3.23. Significantly lower ratios were found in the congenital hypothyroidism group with a mean value of 2.5, due to higher values for free thyroxine compared to free triiodothyronine. Furthermore, an increased free triiodothyronine/ free thyroxine ratio was found at higher thyroid stimulating hormone values due to lower values for free thyroxine. In this study, we demonstrate that the free triiodothyronine/ free thyroxine ratio was significantly lower in children with congenital hypothyroidism compared to the control group. This is most likely due to the higher values for free thyroxine in this group compared to similar values for free triiodothyronine in both groups. Further studies with differentiated thyroid hormone therapy are needed in order to understand the role of peripheral euthyroidism.

Open access

Ningning Gong, Cuixia Gao, Xuedi Chen, Yu Wang, and Limin Tian

Open access

Anna Olsson-Brown, Rosemary Lord, Joseph Sacco, Jonathan Wagg, Mark Coles, and Munir Pirmohamed

clinical trials included both hyperthyroidism and hypothyroidism (Supplementary Table 1, see section on supplementary materials given at the end of this article) but the clinical and biochemical manifestations were not detailed. Radioisotope scanning of