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Thomas Reinehr, Martin Carlsson, Dionisios Chrysis, and Cecilia Camacho-Hübner

–Pyle (GP) ( 1 ) and calculation of predicted height by the method of Bayley–Pinneau (BP) ( 2 ) or the Tanner Whitehouse 2 (TW2) method ( 3 ). While bone age predicts with acceptable accuracy the adult height in healthy children ( 4 , 5 , 6 ), in

Open access

Heike Hoyer-Kuhn, Angela Huebner, Anette Richter-Unruh, Markus Bettendorf, Tilman Rohrer, Klaus Kapelari, Stefan Riedl, Klaus Mohnike, Helmuth-Günther Dörr, Friedrich-Wilhelm Roehl, Katharina Fink, Reinhard W Holl, and Joachim Woelfle

were described in a large cohort of children with CAH from the AQUAPE CAH registry ( 4 ). Treatment in classic CAH is necessary to compensate for glucocorticoid and mineralocorticoid deficiencies and also to blunt the ACTH secretion, the major driver

Open access

Min Yang, Xiangling Deng, Shunan Wang, Bo Zhou, Wenquan Niu, and Zhixin Zhang

Introduction Short stature is increasingly recognized as a worldwide public health concern, and it affects about 3% to 11% of children worldwide ( 1 , 2 , 3 , 4 ). In China, the prevalence of short stature was estimated to be 3.7% among

Open access

Ozlem Atan Sahin, Damla Goksen, Aysel Ozpinar, Muhittin Serdar, and Huseyin Onay

associations between DM1 and VDR genotypes, Bsm IBB ( P  < 0.05), Bsm IBb ( P  < 0.05), Bsm Ibb ( P  < 0.05), Taq ITT ( P  < 0.05) and Taq Itt ( P  < 0.05) in children. This present meta-analysis involves a large data set to investigate the associations

Open access

Ning Yao, Chunbei Zhou, Jun Xie, Xinshu Li, Qianru Zhou, Jing Chen, and Shuang Zhou

Introduction Iodine deficiency disorders (IDD) indicate the broad range of harmful effects due to low level of thyroid hormones in the blood caused by an inadequate dietary supply of iodine ( 1 , 2 ). Pregnant women and young children are

Open access

Anru Wang, Xueqin Yan, Cai Zhang, Caiqi Du, Wenjun Long, Di Zhan, and Xiaoping Luo

Introduction The worldwide prevalence of obesity among children and adolescents has increased in past years ( 1 ). Obesity is associated with insulin resistance, type 2 diabetes mellitus (T2DM) and long-term cardiovascular complications

Open access

Kaiyu Pan, Chengyue Zhang, Xiaocong Yao, and Zhongxin Zhu

intake and better BMD remains controversial ( 5 , 6 ). Therefore, we aimed to determine whether self-reported dietary Ca intake has an influence on BMD in US children and adolescents at 8–19 years of age using the National Health and Nutrition

Open access

Letícia Ribeiro Oliveira, Carlos Alberto Longui, Guilherme Guaragna-Filho, José Luiz Costa, Rafael Lanaro, David Antônio Silva, Maria Izabel Chiamolera, Maricilda Palandi de Mello, André Moreno Morcillo, Andrea Trevas Maciel-Guerra, and Gil Guerra-Junior

complete automation ( 1 , 7 , 8 ). The use of LC-MS/MS in research laboratories has expanded ( 3 , 4 ), because it has proved useful in improving the accuracy of steroid measurements, especially in low concentration samples, as observed in children

Open access

Gudmundur Johannsson, Martin Bidlingmaier, Beverly M K Biller, Margaret Boguszewski, Felipe F Casanueva, Philippe Chanson, Peter E Clayton, Catherine S Choong, David Clemmons, Mehul Dattani, Jan Frystyk, Ken Ho, Andrew R Hoffman, Reiko Horikawa, Anders Juul, John J Kopchick, Xiaoping Luo, Sebastian Neggers, Irene Netchine, Daniel S Olsson, Sally Radovick, Ron Rosenfeld, Richard J Ross, Katharina Schilbach, Paulo Solberg, Christian Strasburger, Peter Trainer, Kevin C J Yuen, Kerstin Wickstrom, Jens O L Jorgensen, and on behalf of the Growth Hormone Research Society

). The requirement for rigorous procedures utilizing biomarkers in drug development is evident and recognized ( 2 , 5 ). The obvious biomarkers of growth hormone (GH) action in children and adults are serum levels of GH itself and of insulin-like growth

Open access

Raja Padidela, Moira S Cheung, Vrinda Saraff, and Poonam Dharmaraj

( 4 ). Trials, in 1- to 12-year-old children, have demonstrated that burosumab improves bone mineral metabolism, heals rickets, which leads to increased growth, mobility, and physical functioning and has the potential to significantly alter the natural