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Martin Zweifel, Beat Thürlimann, Salome Riniker, Patrik Weder, Roger von Moos, Olivia Pagani, Martin Bigler, Karin M Rothgiesser, Christiane Pilop, Hanne Hawle, Peter Brauchli, Coya Tapia, Wolfgang Schoenfeld, Cristiana Sessa, and for the Swiss Group for Clinical Cancer Research (SAKK)

androgen receptor (AR) modulators (SARMs) rather than testosterone may be used to treat AR-positive BC. CR1447 (4-hydroxytestosterone (4-OHT)) is a steroidal small molecule with two distinct properties, acting as a steroidal aromatase inhibitor (AI) and

Open access

Milène Tetsi Nomigni, Sophie Ouzounian, Alice Benoit, Jacqueline Vadrot, Frédérique Tissier, Sylvie Renouf, Hervé Lefebvre, Sophie Christin-Maitre, and Estelle Louiset

profile in an androgen-secreting adrenocortical oncocytoma associated with hirsutism’.

Open access

Jana Ernst, Katharina Gert, Frank Bernhard Kraus, Ulrike Elisabeth Rolle-Kampczyk, Martin Wabitsch, Faramarz Dehghani, and Kristina Schaedlich

androgen levels in the circulation result from an exceeding and dysregulated production of androgens by classical steroidogenic organs ( 6 , 7 ). Classical steroidogenic organs such as the adrenal gland and the gonads are characterized by the presence of

Open access

Monica F Stecchini, Zilda Braid, Candy B More, Davi C Aragon, Margaret Castro, Ayrton C Moreira, and Sonir R Antonini

, but that may be related to the skeletal maturation induced by androgen excess ( 2 ). The development of secondary CPP has been extensively reported in patients with lately diagnosed or poorly controlled congenital adrenal hyperplasia (CAH), and other

Open access

R Walia, M Singla, K Vaiphei, S Kumar, and A Bhansali

of an endocrinologist, a paediatrician, a surgeon, a radiologist, with good laboratory setup. Virilization of external genitalia at birth depends upon intra-uterine exposure to androgens which can be testicular, adrenal or sometimes exogenous in

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Angelica Lindén Hirschberg

elite female athletes concerning the following areas: Mechanisms underlying menstrual disorders Mild and severe forms of hyperandrogenism Sex differences in athletic performance The impact of androgens on physical performance

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Stavroula A Paschou, Eleni Palioura, Dimitrios Ioannidis, Panagiotis Anagnostis, Argyro Panagiotakou, Vasiliki Loi, Georgios Karageorgos, Dimitrios G Goulis, and Andromachi Vryonidou

insulin resistance is positively associated with the degree of hyperandrogenism ( 5 , 6 ) and this was confirmed by a meta-analysis including 32 observational studies and 9556 women with PCOS in total. The higher the levels of androgens, the higher the

Open access

Luigi Laino, Silvia Majore, Nicoletta Preziosi, Barbara Grammatico, Carmelilia De Bernardo, Salvatore Scommegna, Anna Maria Rapone, Giacinto Marrocco, Irene Bottillo, and Paola Grammatico

Testicular DSDs Gonadal dysgenesis DSD 46,XX androgen excess Fetal 21 hydroxylase deficiency Fetal 11 hydroxylase deficiency Fetoplacental aromatase deficiency Maternal luteoma Exogenous androgen excess DSD 46,XX other MURCS, MRKH, and other syndromes DSD 46

Open access

Jin Kyu Oh, Young Jae Im, Kwanjin Park, and Jae-Seung Paick

administration leads to premature termination of pubertal phallic growth. These observations were associated decreased androgen receptor (AR) expression levels before puberty, clearly due to the presence of exogenous testosterone. Moreover, effects on the growth

Open access

Katica Bajuk Studen and Marija Pfeifer

(HR = 2.23, 95% CI 1.86 ± 2.66, P  < 0.001). The incidence of NAFLD increased with increasing androgen and decreasing SHBG levels ( 87 ). NAFLD is associated with increased mortality due to an increased risk from cardiometabolic complications and