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V Guarnotta, C Di Stefano, A Santoro, A Ciresi, A Coppola, and C Giordano

patients with AI and subgroups (A and B) are shown in Table 3 . During the 48-month period of observation 3 out of 47 patients had an adrenal crisis in group A (0.06%) and none in the group B. Table 3 General characteristics of all patients and

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L Ghataore, I Chakraborti, S J Aylwin, K-M Schulte, D Dworakowska, P Coskeran, and N F Taylor

-2-192 ). 12 Hague RV May W Cullen DR . Hepatic microsomal enzyme induction and adrenal crisis due to o,p'DDD therapy for metastatic adrenocortical carcinomas . Clinical Endocrinology 1989 31 51 – 57 . ( doi:10.1111/j.1365-2265.1989.tb00453.x

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Bliss Anderson and Daniel L Morganstein

practice is to reserve high dose corticosteroids for those presenting with adrenal crisis or with significant pituitary enlargement. Other patients can be commenced directly on replacement doses of corticosteroids (e.g. hydrocortisone 20 mg daily in divided

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A C Paepegaey, M Coupaye, A Jaziri, F Ménesguen, B Dubern, M Polak, J M Oppert, M Tauber, G Pinto, and C Poitou

corticotropic axis at the same time as the GH stimulation test by performing an insulin-hypoglycemic test. This should be done systematically, as the clinical signs of central adrenal insufficiency are non-specific, and the consequences of an acute adrenal

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Filippo Ceccato, Elisa Selmin, Chiara Sabbadin, Miriam Dalla Costa, Giorgia Antonelli, Mario Plebani, Mattia Barbot, Corrado Betterle, Marco Boscaro, and Carla Scaroni

, characterized by a concentration peak in the morning and a nadir during the evening ( 7 ). Therefore, it is not uncommon under- or over-exposure to GC treatment: the former induces these patients to the risk of adrenal crisis and fatigue with impaired quality of

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Sirazum Choudhury, Tricia Tan, Katharine Lazarus, and Karim Meeran

.1172/JCI101060 ) 3 Allolio B Extensive expertise in endocrinology. Adrenal crisis . European Journal of Endocrinology 2015 172 R115 – R124 . ( ) 4 Bergthorsdottir R Leonsson-Zachrisson M Oden A

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Jaafar Jaafar, Eugenio Fernandez, Heba Alwan, and Jacques Philippe

considered, followed by oral steroids (such as prednisone) with a dose tapering upon improvement to grade 1, all along with an adequate THR ( 66 , 97 ). A concurrent adrenal insufficiency should be excluded before starting THR because of the risk of adrenal