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Filippo Ceccato, Diego Cecchin, Michele Gregianin, Giacomo Ricci, Cristina Campi, Filippo Crimì, Marta Bergamo, Annibale Versari, Carmelo Lacognata, Federico Rea, Mattia Barbot, and Carla Scaroni

Introduction Cushing’s syndrome (CS), characterized by excessive endogenous cortisol secretion, is in most cases ACTH-dependent. Corticotropin (ACTH) secretion arises from a pituitary adenoma (Cushing’s disease) or, less frequently, from a non

Open access

Peter Wolf, Yvonne Winhofer, Martin Krššák, and Michael Krebs

metabolic comorbidities in Cushing’s disease including dyslipidemia and the high prevalence of T2DM, it is tempting to speculate about glucolipotoxic effects on the heart, although no data on ectopic lipid accumulation in the heart in endogenous

Open access

Soraya Puglisi, Paola Perotti, Mattia Barbot, Paolo Cosio, Carla Scaroni, Antonio Stigliano, Pina Lardo, Valentina Morelli, Elisa Polledri, Iacopo Chiodini, Giuseppe Reimondo, Anna Pia, and Massimo Terzolo

to thank Silvia Fustinoni for assistance with lab assays. References 1 Feelders RA Pulgar SJ Kempel A Pereira AM . The burden of Cushing’s disease: clinical and health-related quality of life aspects . European Journal of Endocrinology

Open access

Ferdinand Roelfsema, Diana van Heemst, Ali Iranmanesh, Paul Takahashi, Rebecca Yang, and Johannes D Veldhuis

night. For diagnostic considerations, these subtle physiological adaptations are not relevant in diagnosing major endocrine disruptions such as Cushing’s disease, Cushing’s syndrome and primary and secondary adrenal failure. For these disorders

Open access

Anne Jouinot, Bernard Royer, Etienne Chatelut, Sotheara Moeung, Guillaume Assié, Audrey Thomas-Schoemann, Jérôme Bertherat, François Goldwasser, and Benoit Blanchet

Bou Khalil R Silvera S Guignat L Guibourdenche J Abbas H Legmann P Bertagna X Bertherat J. Efficiency and tolerance of mitotane in Cushing’s disease in 76 patients from a single center . European Journal of Endocrinology 2012 167 473 – 481

Open access

Mônica R Gadelha, Feng Gu, Marcello D Bronstein, Thierry C Brue, Maria Fleseriu, Ilan Shimon, Aart J van der Lely, Shoba Ravichandran, Albert Kandra, Alberto M Pedroncelli, and Annamaria A L Colao

acromegaly can be obtained. However, experience with managing pasireotide-related hyperglycemia in patients with Cushing’s disease has led to the following recommendations on managing elevated blood glucose levels in these patients. Hyperglycemia should be

Open access

J Brossaud, V Pallet, and J-B Corcuff

to treat Cushing’s disease ( 65 ). Ectopic ACTH secretion may also be affected by retinoids. Indeed, the nuclear co-repressor SMRT is over-expressed in ACTH-secreting thymic carcinoids suggesting that aberrant expression might be involved in the

Open access

Athanasios Zervas, George Chrousos, and Sarantis Livadas

cause Cushing’s disease . Nature Genetics 2015 47 31 ‐ 38 . ( ) 34 Guaraldi F Storr HL Ghizzoni L Ghigo E Savage MO Paediatric pituitary adenomas: a decade of change . Hormone Research in Paediatrics

Open access

G Giuffrida, F Ferraù, R Laudicella, O R Cotta, E Messina, F Granata, F F Angileri, A Vento, A Alibrandi, S Baldari, and S Cannavò

pituitary carcinoma causing Cushing’s disease - report of a case and literature review . ScientificWorldJournal 2010 10 2132 – 2138 . ( ) 10.1100/tsw.2010.210 21057727 28 Losa M Bogazzi F Cannavo S Ceccato F

Open access

Zeeshan Javed, Maria Papageorgiou, Leigh A Madden, Alan S Rigby, Eric S Kilpatrick, Stephen L Atkin, and Thozhukat Sathyapalan

deficiency, hyperprolactinaemia, Cushing’s disease and androgen-secreting tumours, pregnancy or intention to become pregnant, breastfeeding, documented use of oral hormonal contraceptives and hormone-releasing implants, metformin or other insulin