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Stavroula Stavrou, Michael Gratz, Eileen Tremmel, Christina Kuhn, Simone Hofmann, Helene Heidegger, Mina Peryanova, Kerstin Hermelink, Stefan Hutter, Bettina Toth, Doris Mayr, Sven Mahner, Udo Jeschke, and Aurelia Vattai

maintenance of an euthyroid state is crucial for a healthy pregnancy ( 2 ). Thyroid hormones, which bind to the thyroid hormone receptor (THR), play an important role during trophoblast differentiation and the development of the foetal nervous system ( 3

Open access

Ulla Schmidt, Birte Nygaard, Ebbe Winther Jensen, Jan Kvetny, Anne Jarløv, and Jens Faber

1- and 2-deiodinase activate T 4 into T 3 and type 3-deiodinase inactivate T 3 , and finally, by binding to specific thyroid hormone nuclear receptors (1) . Different tissues have different metabolic pathways, making it difficult to quantify the

Open access

Jiashu Li, Aihua Liu, Haixia Liu, Chenyan Li, Weiwei Wang, Cheng Han, Xinyi Wang, Yuanyuan Zhang, Weiping Teng, and Zhongyan Shan

, body mass index; FT 4 , free thyroxine; TgAb, thyroglobulin antibody; TPOAb, thyroid-peroxidase antibody; TSH, thyroid-stimulating hormone. Gestational age when the miscarriages occurred Among the 421 women with a miscarriage, the median

Open access

Lauren Bell, Ann Louise Hunter, Angelos Kyriacou, Annice Mukherjee, and Akheel A Syed

of GD including orbitopathy, thyroid dermopathy (pretibial myxoedema) and thyroid acropachy. Serum analyses typically show suppressed thyroid-stimulating hormone (TSH; thyrotropin) and elevated thyroid hormones, tetraiodothyronine (T4; thyroxine) and

Open access

Yi Chen, Wen Zhang, Chi Chen, Yuying Wang, Ningjian Wang, and Yingli Lu

-terminal propeptide; SPINA-G T , thyroid’s secretory capacity; SPINA-G D , sum activity of peripheral deiodinases; TgAb, thyroglobulin antibody; TPOAb, thyroid peroxidase antibody; TSH, thyroid-stimulating hormone; TSHI, Jostel’s TSH index; TT 3 , total

Open access

Luchuan Li, Baoyuan Li, Bin Lv, Weili Liang, Binbin Zhang, Qingdong Zeng, Andrew G Turner, and Lei Sheng

; lBUN, blood urea nitrogen; Cr, creatinine; ln, natural logarithm; PHPT, primary hyperparathyroidism; PTH, parathyroid hormone; TgAb, thyroglobulin antibody; TPOAb, thyroid peroxidase antibody; TSH, thyroid-stimulating hormone. A

Open access

Michael J Gratz, Stavroula Stavrou, Christina Kuhn, Simone Hofmann, Kerstin Hermelink, Helene Heidegger, Stefan Hutter, Doris Mayr, Sven Mahner, Udo Jeschke, and Aurelia Vattai

to the thyroid hormone receptor (THR), which belongs to the nuclear receptor superfamily. Nuclear receptors play a role in various physiological processes, and they act via transcriptional cis-regulation of target genes ( 10 ). The choline

Open access

Boni Xiang, Ran Tao, Xinhua Liu, Xiaoming Zhu, Min He, Zengyi Ma, Yehong Yang, Zhaoyun Zhang, Yiming Li, Zhenwei Yao, Yongfei Wang, and Hongying Ye

decreased iodine-131 (I 131 ) accumulation in the thyroid of euthyroid patients ( 3 ). Dexamethasone administration (16 mg daily for 2.5 days) was reported to reduce the thyroid-stimulating hormone (TSH) and free T3 (FT3) secretion and blunted the TSH

Open access

Kusum Lata, Pinaki Dutta, Subbiah Sridhar, Minakshi Rohilla, Anand Srinivasan, G R V Prashad, Viral N Shah, and Anil Bhansali

increased risk of progression to subclinical hypothyroidism, or it could be due to the transplacental transfer of thyroid receptor blocking antibodies (10, 11) . Hence, there is a need to screen for subclinical hypothyroidism and thyroid autoimmunity in

Open access

Antonina Khoruzhenko, Françoise Miot, Claude Massart, Jacqueline Van Sande, Jacques Emile Dumont, Renaud Beauwens, and Alain Boom

Yamaguchi S Shibuya M Stimulation by thyroid-stimulating hormone and Grave’s immunoglobulin G of vascular endothelial growth factor mRNA expression in human thyroid follicles in vitro and mRNA expression in the rat thyroid in vivo . Journal of Clinical