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of empagliflozin using the euglycemic hyperinsulinemic glucose clamp technique with the STG-55 artificial pancreas model (Nikkiso, Tokyo, Japan), as previously described ( 15 , 16 ). In brief, regular insulin (Humalin R; Eli Lilly & Co.) was loaded

employed the euglycemic hyperinsulinemic clamp technique (29) to study whether insulin affects markers of bone remodeling, particularly OC, in humans. A few studies have applied this technique to assess acute insulin-driven changes in bone metabolism (30

concentrations traceable to purified CD163. The inter-assay imprecision was <5% CV. The limit of detection was 6.25 µg/L. Soluble CD163 is robust to thawing and prolonged freezing ( 22 ). Hyperinsulinemic–euglycemic clamp As previously described ( 24

been shown to be inversely correlated with glucose uptake in the left ventricle of the heart during an euglycemic hyperinsulinemic clamp in m.3243A>G carriers ( 39 ). Furthermore, glycolysis and insulin signaling are suppressed in red fibers of

/mL. Hyperinsulinemic-euglycemic clamp Two peripheral venous catheters were placed in each arm (antebrachial veins) of the participants. One catheter was used to infuse insulin (Actrapid, Novo Nordisk, Bagsvaerd, Denmark) at a primed (240 mU/m 2 ), continuous rate of

quantifying the insulin secretion by β-cells after glucose stimulation is hyperglycemic and euglycemic hyperinsulinemic glucose clamp. This method measures how well an individual metabolizes glucose and how sensitive an individual responds to insulin ( 7

pregnancy ( 7 ). Thus, identifying IR status could be beneficial for diagnosing GDM. However, current assessment methods, hyperinsulinemic-euglycemic clamp (HEC) and homeostatic model assessment for insulin resistance (HOMA-IR), are inconvenient to use in

DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp . Diabetes Care 1999 22 1462 – 1470 . ( https://doi.org/10.2337/diacare.22.9.1462 ). 10.2337/diacare.22

contributes to many metabolic disorders, including hypercoagulation, hypo-fibrinolysis, dyslipidemia and hypertension ( 3 ). The hyperinsulinemic-euglycemic clamp technique is the gold standard for evaluating insulin resistance in humans but is costly for

. Insulin sensitivity was assessed using the hyperinsulinemic and euglycemic clamp technique. All volunteers received oral and written information concerning the study before giving written and informed consent. The protocol was approved by the Aarhus County