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Yuka Goto, Yoshie Otsuka, Kenji Ashida, Ayako Nagayama, Nao Hasuzawa, Shimpei Iwata, Kento Hara, Munehisa Tsuruta, Nobuhiko Wada, Seiichi Motomura, Yuji Tajiri, and Masatoshi Nomura

of empagliflozin using the euglycemic hyperinsulinemic glucose clamp technique with the STG-55 artificial pancreas model (Nikkiso, Tokyo, Japan), as previously described ( 15 , 16 ). In brief, regular insulin (Humalin R; Eli Lilly & Co.) was loaded

Open access

Kaisa K Ivaska, Maikki K Heliövaara, Pertti Ebeling, Marco Bucci, Ville Huovinen, H Kalervo Väänänen, Pirjo Nuutila, and Heikki A Koistinen

employed the euglycemic hyperinsulinemic clamp technique (29) to study whether insulin affects markers of bone remodeling, particularly OC, in humans. A few studies have applied this technique to assess acute insulin-driven changes in bone metabolism (30

Open access

Ermina Bach, Niels Møller, Jens Otto L Jørgensen, Mads Buhl, and Holger Jon Møller

concentrations traceable to purified CD163. The inter-assay imprecision was <5% CV. The limit of detection was 6.25 µg/L. Soluble CD163 is robust to thawing and prolonged freezing ( 22 ). Hyperinsulinemic–euglycemic clamp As previously described ( 24

Open access

Jakob Høgild Langdahl, Anja Lisbeth Frederiksen, John Vissing, Morten Frost, Knud Bonnet Yderstræde, and Per Heden Andersen

been shown to be inversely correlated with glucose uptake in the left ventricle of the heart during an euglycemic hyperinsulinemic clamp in m.3243A>G carriers ( 39 ). Furthermore, glycolysis and insulin signaling are suppressed in red fibers of

Open access

Anouar Aznou, Rick Meijer, Daniel van Raalte, Martin den Heijer, Annemieke Heijboer, and Renate de Jongh

/mL. Hyperinsulinemic-euglycemic clamp Two peripheral venous catheters were placed in each arm (antebrachial veins) of the participants. One catheter was used to infuse insulin (Actrapid, Novo Nordisk, Bagsvaerd, Denmark) at a primed (240 mU/m 2 ), continuous rate of

Open access

Li Li, Qifa Song, and Xi Yang

quantifying the insulin secretion by β-cells after glucose stimulation is hyperglycemic and euglycemic hyperinsulinemic glucose clamp. This method measures how well an individual metabolizes glucose and how sensitive an individual responds to insulin ( 7

Open access

Yusen Liu, Ruiwen Chi, Yujie Jiang, Bicheng Chen, Youli Chen, and Zengrui Chen

pregnancy ( 7 ). Thus, identifying IR status could be beneficial for diagnosing GDM. However, current assessment methods, hyperinsulinemic-euglycemic clamp (HEC) and homeostatic model assessment for insulin resistance (HOMA-IR), are inconvenient to use in

Open access

Krzysztof C Lewandowski, Justyna Płusajska, Wojciech Horzelski, Ewa Bieniek, and Andrzej Lewiński

DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp . Diabetes Care 1999 22 1462 – 1470 . ( ). 10.2337/diacare.22

Open access

Hong Wang, Jie Cao, Jian-bin Su, Xue-qin Wang, Dong-mei Zhang, and Xiao-hua Wang

contributes to many metabolic disorders, including hypercoagulation, hypo-fibrinolysis, dyslipidemia and hypertension ( 3 ). The hyperinsulinemic-euglycemic clamp technique is the gold standard for evaluating insulin resistance in humans but is costly for

Open access

Henrik H Thomsen, Holger J Møller, Christian Trolle, Kristian A Groth, Anne Skakkebæk, Anders Bojesen, Christian Høst, and Claus H Gravholt

. Insulin sensitivity was assessed using the hyperinsulinemic and euglycemic clamp technique. All volunteers received oral and written information concerning the study before giving written and informed consent. The protocol was approved by the Aarhus County