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Kamran Iqbal, Kate Halsby, Robert D Murray, Paul V Carroll, and Robert Petermann

information is well recorded and accurate ( 13 , 14 ). Study population The population of interest comprised patients with treated AI defined as an AI-specific Read code and at least one Multilex code for the corticosteroids of interest (i.e. IR HC

Open access

Stephanie E Baldeweg, Mark Vanderpump, Will Drake, Narendra Reddy, Andrew Markey, Gordon T Plant, Michael Powell, Saurabh Sinha, John Wass, and the Society for Endocrinology Clinical Committee

emergencies. Prompt resuscitation and corticosteroid replacement may be lifesaving. MRI scan is the investigation of choice. Urgent discussion with the regional neurosurgical/endocrine team is essential. Surgical intervention should be considered in

Open access

Marcus Quinkler, Bertil Ekman, Claudio Marelli, Sharif Uddin, Pierre Zelissen, Robert D Murray, and on behalf of the EU-AIR Investigators

development of corticosteroid side effects between patients ( 7 ). Interestingly, when the endogenous glucocorticoid, cortisol (hydrocortisone), is compared with prednisolone at the isolated human glucocorticoid receptor (GR), the transactivation activity of

Open access

Greta B Raglan, Louis A Schmidt, and Jay Schulkin

as a possible intervention for mental illness including depression. Although further study is necessary, it appears that corticosteroid synthesis inhibitors (CSIs) may show some efficacy in treating individuals with intractable depression ( 23

Open access

Martijn J J Finken, Aleid J G Wirix, Ines A von Rosenstiel-Jadoul, Bibian van der Voorn, Mai J M Chinapaw, Michaela F Hartmann, Joana E Kist-van Holthe, Stefan A Wudy, and Joost Rotteveel

, raised blood pressure, insulin resistance, and dyslipidemia ( 7 , 10 ). There is controversy as to whether increased HPA axis activity is a cause or a consequence of childhood obesity. It has been demonstrated that the rise in serum corticosteroids

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Bliss Anderson and Daniel L Morganstein

practice is to reserve high dose corticosteroids for those presenting with adrenal crisis or with significant pituitary enlargement. Other patients can be commenced directly on replacement doses of corticosteroids (e.g. hydrocortisone 20 mg daily in divided

Open access

Hanna F Nowotny, Jillian Bryce, Salma R Ali, Roberta Giordano, Federico Baronio, Irina Chifu, Lea Tschaidse, Martine Cools, Erica LT van den Akker, Henrik Falhammar, Natasha M Appelman-Dijkstra, Luca Persani, Guglielmo Beccuti, Ian L Ross, Simona Grozinsky-Glasberg, Alberto M Pereira, Eystein S Husebye, Stefanie Hahner, S Faisal Ahmed, and Nicole Reisch

stress-related cortisol rise by the interference of antibodies directed against those viral antigens with the host’s natural secretion of corticosteroids ( 8 ). Recent studies in patients with SARS-CoV-2 infections confirmed significantly impaired

Open access

L Ghataore, I Chakraborti, S J Aylwin, K-M Schulte, D Dworakowska, P Coskeran, and N F Taylor

cortisol due to rapid conversion by CYP3A4 in the liver, perhaps during a first pass after adsorption from the gut. A second factor may be an increase in corticosteroid binding globulin during mitotane treatment (23) . Induction of CYP3A4 by mitotane needs

Open access

Xiaowen Zhang, Chen Han, Hongwei Wang, Xinghong Sun, Xin Dou, Xueying He, Di Wu, Shanmei Shen, Dalong Zhu, Xinlin Zhang, and Yan Bi

corticosteroid treatment could impact NLR values and MR findings, we performed a separate analysis excluding those who were receiving or have received corticosteroid treatments over 3 months before enrollment. A Cox proportional hazards model was used to identify

Open access

Anne-Sophie C A M Koning, Philippe C Habets, Marit Bogaards, Jan Kroon, Hanneke M van Santen, Judith M de Bont, and Onno C Meijer

presence of both GR and MR in dexamethasone-exposed human hippocampal tissue We next visualized the subcellular distribution of the corticosteroid receptors in the human hippocampus. As expected, IF staining of GR in the dexamethasone-treated tissue