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Kim K B Clemmensen, Jonas S Quist, Dorte Vistisen, Daniel R Witte, Anna Jonsson, Oluf Pedersen, Torben Hansen, Jens J Holst, Torsten Lauritzen, Marit E Jørgensen, Signe Torekov, and Kristine Færch

). Additionally, the time of the day of an OGTT seems to influence the glucose response with higher post-load blood glucose levels in the afternoon and evening compared to the morning ( 1 , 3 ). The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose

Open access

Giovanni Fanni, Petros Katsogiannos, Bipasha Nandi Jui, Magnus Sundbom, Susanne Hetty, Maria J Pereira, and Jan W Eriksson

immediately performed, were frozen and stored at −80°C. For analyses, commercially available ELISA or multiplex kits were used: glucagon and glicentin (Mercodia, Uppsala, Sweden); total glucagon-like peptide (GLP)-1 (7-36 and 9-36) and total glucose

Open access

Benjamin Paul Green, Javier Thomas Gonzalez, Kevin Thomas, Emma Stevenson, and Penny Louise Sheena Rumbold

tract, pancreas, and adipose, act to influence the physiological mechanisms controlling energy regulation, eliciting divergent actions on feeding behaviour and metabolism (1) . In humans, hormonal peptides such as glucagon-like peptide-1 (GLP1) (2

Open access

Lili Liu, Zhuo Shao, Ying Xia, Jiabi Qin, Yang Xiao, Zhiguang Zhou, and Zubing Mei

. Incretin-based drugs, including glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dipeptidyl peptidase 4 (DPP-4) inhibitors, may offer an opportunity to avoid these side effects. Theoretically, GLP-1 RAs are structurally and functionally similar to

Open access

Shin-ya Ueda, Hidehiro Nakahara, Eriko Kawai, Tatsuya Usui, Shintaro Tsuji, and Tadayoshi Miyamoto

glucagon-like peptide-1 (GLP-1), peptide YY (PYY) and ghrelin ( 2 ). The effects of exercise on these hormones have been investigated extensively over the past decade ( 3 , 4 ). Previous findings suggested that the concentrations of anorexigenic hormones

Open access

Agnieszka Kosowska, Enrique Gallego-Colon, Wojciech Garczorz, Agnieszka Kłych-Ratuszny, Mohammad Reza F Aghdam, Michał Woz´niak, Andrzej Witek, Agnieszka Wróblewska-Czech, Anna Cygal, Jerzy Wojnar, and Tomasz Francuz

mechanism of action of incretin mimetic drugs is through the binding to glucagon-like peptide-1 receptor (GLP-1R) in pancreatic beta cells stimulating insulin secretion. The two most important natural incretin hormones are glucagon-like peptide-1 (GLP-1) and

Open access

Lizhi Zhang, Jinwei He, Xiang Sun, Dongyue Pang, Jingjing Hu, and Bo Feng

). Some drugs commonly used to regulate blood sugar, such as glucagon-like peptide-1 (GLP-1) receptor agonists and DPP-4 inhibitors (DPP-4is), can inhibit bone resorption and improve bone formation ( 2 , 3 , 4 , 5 , 6 , 7 ). GLP-1 is a DPP-4 substrate

Open access

Amalie R Lanng, Lærke S Gasbjerg, Natasha C Bergmann, Sigrid Bergmann, Mads M Helsted, Matthew P Gillum, Bolette Hartmann, Jens J Holst, Tina Vilsbøll, and Filip K Knop

). Likewise, the effect of alcohol on the secretion of the gut-derived insulinotropic incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) remains unclear ( 6 , 11 , 12 ). Recently, alcohol was shown to

Open access

M Jensterle, A Podbregar, K Goricar, N Gregoric, and A Janez

almost exclusively due to loss of body fat ( 6 ). In selected patients, TRT could be started concomitantly or in addition to LSM to augment the benefits of LSM, although the quality of evidence supporting this concept is low ( 2 ). GLP1 receptor

Open access

Henri Honka, Jukka Koffert, Saila Kauhanen, Nobuyuki Kudomi, Saija Hurme, Andrea Mari, Andreas Lindqvist, Nils Wierup, Riitta Parkkola, Leif Groop, and Pirjo Nuutila

incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) account for the gut-derived amplification of insulin secretion ( 4 ). In addition to the effect on pancreatic islets, we ( 5 ) and others ( 6 ) have