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Boni Xiang, Ran Tao, Xinhua Liu, Xiaoming Zhu, Min He, Zengyi Ma, Yehong Yang, Zhaoyun Zhang, Yiming Li, Zhenwei Yao, Yongfei Wang, and Hongying Ye

(ACTH)-dependent ( 1 ), and 20% is ACTH-independent. Pituitary corticotroph adenoma (Cushing’s disease (CD)) is the most common cause ( 2 ), followed by primary unilateral adrenal adenomas and ectopic adrenocorticotropic syndrome (EAS). The clinical

Open access

Nidan Qiao

pituitary neoplasms, acromegaly, Cushing’s disease, craniopharyngioma and growth hormone deficiency. More than half of the studies were published in the recent 2 years. Table 2 Summary of studies on sellar region disease using machine learning methods

Open access

Jingya Zhou, Meng Zhang, Lin Lu, Xiaopeng Guo, Lu Gao, Weigang Yan, Haiyu Pang, Yi Wang, and Bing Xing

(ACTH)-dependent and ACTH-independent etiologies. The former includes Cushing’s disease (CD) and ectopic ACTH syndrome (EAS), and the latter includes adrenocortical adenoma (ACA), adrenocortical carcinoma (ACC), primary bilateral macronodular adrenal

Open access

Ida Staby, Jesper Krogh, Marianne Klose, Jonas Baekdal, Ulla Feldt-Rasmussen, Lars Poulsgaard, Jacob Bertram Springborg, and Mikkel Andreassen

/oligomenorrhoea for premenopausal women. A diagnosis of Cushing’s disease or acromegaly was established according to the standard criteria. We did not report on GH deficiency or anti-diuretic hormone insufficiency because only a few patients were examined with GH

Open access

Benedetta Zampetti, Erika Grossrubatscher, Paolo Dalino Ciaramella, Edoardo Boccardi, and Paola Loli

use of more stringent criteria to define responsiveness to the diagnostic tests increases the ability to differentiate Cushing’s disease (CD) from EAS, but invariably leads to reduced diagnostic sensitivity ( 12 ). On the other hand, dynamic gadolinium

Open access

Solène Castellnou, Alexandre Vasiljevic, Véronique Lapras, Véronique Raverot, Eudeline Alix, Françoise Borson-Chazot, Emmanuel Jouanneau, Gérald Raverot, and Hélène Lasolle

Introduction Cushing’s disease is a rare disorder defined as chronic hypercortisolism due to a corticotropin-secreting pituitary tumor (corticotroph tumor) ( 1 ). Chronic cortisol excess is responsible for multisystem morbidity, contributing

Open access

Carla Scaroni, Nora M Albiger, Serena Palmieri, Davide Iacuaniello, Chiara Graziadio, Luca Damiani, Marialuisa Zilio, Antonio Stigliano, Annamaria Colao, Rosario Pivonello, and the Altogether to Beat Cushing’s Syndrome (ABC) study group

ACS, adrenal Cushing’s syndrome; CD, Cushing’s disease; CS, Cushing’s syndrome; CS-E, Cushing’s syndrome excluded; CT, controls; Dexa, dexamethasone; Dexa-CRH test, dexamethasone-suppressed corticotropin-releasing hormone test; EAS, ectopic ACTH

Open access

Bjørn O Åsvold, Valdemar Grill, Ketil Thorstensen, and Marit R Bjørgaas

repeated the analyses, omitting these two subjects, as well as the three subjects with previous treatment for Cushing's disease. The data were analyzed using Stata version 10.1 for Windows (Stata Corp., College Station, TX, USA). The samples were collected

Open access

Filippo Ceccato, Diego Cecchin, Michele Gregianin, Giacomo Ricci, Cristina Campi, Filippo Crimì, Marta Bergamo, Annibale Versari, Carmelo Lacognata, Federico Rea, Mattia Barbot, and Carla Scaroni

Introduction Cushing’s syndrome (CS), characterized by excessive endogenous cortisol secretion, is in most cases ACTH-dependent. Corticotropin (ACTH) secretion arises from a pituitary adenoma (Cushing’s disease) or, less frequently, from a non

Open access

Hershel Raff and Hariprasad Trivedi

caution. Whereas this measurement has a 95% sensitivity and specificity for Cushing's syndrome in patients without chronic kidney disease (6) , we now suggest an increased likelihood of false-positive results in patients with ESRD, particularly