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Michael Ulm, Arvind V Ramesh, Keely M McNamara, Suriyan Ponnusamy, Hironobu Sasano, and Ramesh Narayanan

.0b013e31823874a4 ) 10.2310/JIM.0b013e31823874a4 16 Kim EH Brockman JA Andriole GL. The use of 5-alpha reductase inhibitors in the treatment of benign prostatic hyperplasia . Asian Journal of Urology 2018 5 28 – 32 . (

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Karim Gariani and François R Jornayvaz

:// ). 83 Livingstone DE Barat P Di Rollo EM Rees GA Weldin BA Rog-Zielinska EA MacFarlane DP Walker BR Andrew R 5Alpha-reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic

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Clarissa Souza Barthem, Camila Lüdke Rossetti, Denise P Carvalho, and Wagner Seixas da-Silva

: protein kinase AMP-activated catalytic subunit alpha 1 ( Prkaa1 ) and alpha 2 ( Prkaa2 ) ( Fig. 4D ). Figure 4 AMPK levels in the liver. (A) Western blotting for pAMPK ( n  = 8–10) and (B) total AMPK (tAMPK) ( n  = 5). Fifteen micrograms of total

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Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant, and Agnès Linglart

’Neil DM Libé R Allolio B Bertagna X Bertherat J , et al . Mitotane therapy in adrenocortical cancer induces CYP3A4 and inhibits 5alpha-reductase, explaining the need for personalized glucocorticoid and androgen replacement . Journal of Clinical

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Stephen J Winters, Charles R Scoggins, Duke Appiah, and Dushan T Ghooray

). SHBG levels are lower with obesity ( 2 ) and in patients with type 2 (T2DM) but not type 1 diabetes ( 3 , 4 ), and in those with the metabolic syndrome (MetS) ( 5 ). Moreover, a low level of SHBG is associated with an increased risk for developing MetS

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Ningning Gong, Cuixia Gao, Xuedi Chen, Yu Wang, and Limin Tian

atherosclerosis (AS) was reported in a large population-based study ( 2 , 3 ). Multiple lines of evidence have shown that adipokines ( 4 ), endothelial dysfunction ( 5 ) and dyslipidemia ( 6 ) play a central role in the development of AS, but the relationship

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Lisette van Alewijk, Kirsten Davidse, Karlijn Pellikaan, Judith van Eck, Anita C S Hokken-Koelega, Theo C J Sas, Sabine Hannema, Aart J van der Lely, and Laura C G de Graaff

-alpha reductase deficiency could be harder to remember than disorders like Klinefelter syndrome, this might suggest that almost one-third of the patients are not sufficiently informed about their condition at the moment of transfer to adult healthcare

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Kylie D Rock, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather M Stapleton, and Heather B Patisaul

.1016/j.brainresrev.2010.06.002 ) 10.1016/j.brainresrev.2010.06.002 20550950 51 Poletti A Celotti F Rumio C Rabuffetti M Martini L . Identification of type 1 5alpha-reductase in myelin membranes of male and female rat brain. Molecular and Cellular

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Sebastião Freitas de Medeiros, Cinthia Marenza Ormond, Matheus Antônio Souto de Medeiros, Nayara de Souza Santos, Camila Regis Banhara, and Márcia Marly Winck Yamamoto

cytochrome P450c17alpha dysregulation . Human Reproduction 1997 12 910 – 913 . ( doi:10.1093/humrep/12.5.910 ) 10.1093/humrep/12.5.910 13 Lobo RA Goebelsmann UWE. Evidence for reduced 3β-ol-hydroxysteroid dehydrogenase activity in some

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Annette Mouritsen, Alexander Siegfried Busch, Lise Aksglaede, Ewa Rajpert-De Meyts, and Anders Juul

15 and UGT2B17 are critical enzymes for the local inactivation of androgens ( 5 ). The circulating T is converted to DHT, a potent androgen receptor agonist, by 5α-reductase. As it is extremely important to modulate DHT levels locally, the