Introduction Low testosterone as well as high C-reactive protein (CRP) levels have been associated with increased risk for all-cause mortality in men ( 1 , 2 , 3 , 4 ). Testosterone concentration decreases with aging, and if reaching
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Amar Osmancevic, Kristin Ottarsdottir, Margareta Hellgren, Ulf Lindblad, and Bledar Daka
Manjeetkaur Sehemby, Prachi Bansal, Vijaya Sarathi, Ashwini Kolhe, Kanchan Kothari, Swati Jadhav-Ramteke, Anurag R Lila, Tushar Bandgar, and Nalini S Shah
), hormonal evaluation (follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone), imaging details (transabdominal sonography, computed tomography/magnetic resonance imaging), surgical details and follow-up of the patients were collected
Letícia Ribeiro Oliveira, Carlos Alberto Longui, Guilherme Guaragna-Filho, José Luiz Costa, Rafael Lanaro, David Antônio Silva, Maria Izabel Chiamolera, Maricilda Palandi de Mello, André Moreno Morcillo, Andrea Trevas Maciel-Guerra, and Gil Guerra-Junior
with DSD ( 2 ). One of the most important challenge is the measurement of testosterone concentration ( 9 , 10 ), especially in the investigation of 46,XY DSD cases. DSD are congenital conditions in which chromosomal, gonadal or anatomical sex is
Simon Chang, Arkadiusz J Goszczak, Anne Skakkebæk, Jens Fedder, Anders Bojesen, M Vakur Bor, Moniek P M de Maat, Claus H Gravholt, and Anna-Marie B Münster
demonstrated in non-KS obese men with hypogonadism ( 14 ) and data from several studies have demonstrated an array of effects of androgenic compounds on fibrinolytic markers, collectively suggesting that normal plasma testosterone actively supports fibrinolysis
Teresa Lam, Mark McLean, Amy Hayden, Anne Poljak, Birinder Cheema, Howard Gurney, Glenn Stone, Neha Bahl, Navneeta Reddy, Haleh Shahidipour, and Vita Birzniece
Introduction Sarcopenia, the age-related loss of muscle mass and function, presents an escalating public health burden, contributing to increased falls, disability and loss of functional independence ( 1 ). In men, testosterone is critical for
Milène Tetsi Nomigni, Sophie Ouzounian, Alice Benoit, Jacqueline Vadrot, Frédérique Tissier, Sylvie Renouf, Hervé Lefebvre, Sophie Christin-Maitre, and Estelle Louiset
hyperandrogenism (5, 6) . They are commonly associated with high testosterone levels (7, 8) . High plasma levels of testosterone associated with normal dehydroepiandrosterone sulfate (DHEAS) concentration are indicative of ovarian hyperthecosis or androgen
Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara Obermayer-Pietsch, and Elisabeth Lerchbaum
-based studies found that in 30–40% of infertile couples, the underlying cause is the male factor ( 13 ). One major aspect regarding male fertility is the complex interaction between pituitary gland and testis. Of note, testosterone is not only an important
Florian Schederecker, Alexander Cecil, Cornelia Prehn, Jana Nano, Wolfgang Koenig, Jerzy Adamski, Tanja Zeller, Annette Peters, and Barbara Thorand
cancers ( 1 , 2 , 3 ). In women with hyperandrogenism, an increased prevalence of metabolic risk factors and risk of type 2 diabetes (T2D) and cardiovascular disease (CVD) has been observed ( 4 , 5 , 6 ). In men, high testosterone levels are associated
Morten Ruge, Tea Skaaby, Anna-Maria Andersson, and Allan Linneberg
Introduction Male hypogonadism is a condition in which the body produces little or no testosterone, and the risk is increased in the middle- and older-aged male population ( 1 ). The primary symptoms are reduced libido, lack of effect of
Claus H Gravholt, Alberto Ferlin, Joerg Gromoll, Anders Juul, Armin Raznahan, Sophie van Rijn, Alan D Rogol, Anne Skakkebæk, Nicole Tartaglia, and Hanna Swaab
found diminished bone mineral density (BMD) and increased risk of vertebral fractures in subjects with Klinefelter syndrome ( 18 , 19 , 20 ). Testosterone replacement therapy (TRT) increases BMD in men with Klinefelter syndrome ( 21 , 22 ), but there
