GH insensitivity syndrome (GHIS) and in pubertal age did not have any secondary sexual characteristics ( 12 ). Ten years later, they found these puberty alterations on seven boys with Laron syndrome. One of them, aged 20 years, did not show signs of
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Rossella Cannarella, Andrea Crafa, Sandro La Vignera, Rosita A Condorelli, and Aldo E Calogero
Sakina Kherra, Wendy Forsyth Paterson, Filiz Mine Cizmecioglu, Jeremy Huw Jones, Mariam Kourime, Heba Hassan Elsedfy, Sameh Tawfik, Andreas Kyriakou, Mohamad Guftar Shaikh, and Malcolm David Cairns Donaldson
Y Oto Y Itabashi H Shiraishi M Yoshino A Tanaka Y Obata K Murakami N et al . Testosterone replacement therapy to improve secondary sexual characteristics and body composition without adverse behavioral problems in adult male patients
Athanasios Zervas, George Chrousos, and Sarantis Livadas
time of diagnosis. At the onset of puberty, many patients with PROP1 mutations also exhibit LH and FSH deficiency and fail to develop secondary sexual characteristics (possibly applicable to Dopey). The loss of gonadotropins may also present as an
Silvia Ciancia, Vanessa Dubois, and Martine Cools
youth healthcare. Current guidelines recommend the use of GnRH analogs (GnRHa) to suppress puberty and prevent the development of secondary sexual characteristics. At ages 15–16 years, gender-affirming hormones (GAH) are usually added (non
Anita Hokken-Koelega, Aart-Jan van der Lely, Berthold Hauffa, Gabriele Häusler, Gudmundur Johannsson, Mohamad Maghnie, Jesús Argente, Jean DeSchepper, Helena Gleeson, John W Gregory, Charlotte Höybye, Fahrettin Keleştimur, Anton Luger, Hermann L Müller, Sebastian Neggers, Vera Popovic-Brkic, Eleonora Porcu, Lars Sävendahl, Stephen Shalet, Bessie Spiliotis, and Maithé Tauber
Tanaka Y Obata K Murakami N Testosterone replacement therapy to improve secondary sexual characteristics and body composition without adverse behavioral problems in adult male patients with Prader-Willi syndrome: an observational study
A C Paepegaey, M Coupaye, A Jaziri, F Ménesguen, B Dubern, M Polak, J M Oppert, M Tauber, G Pinto, and C Poitou
2578 – 2585 . 38 Kido Y Sakazume S Abe Y Oto Y Itabashi H Shiraishi M Yoshino A Tanaka Y Obata K Murakami N , et al . Testosterone replacement therapy to improve secondary sexual characteristics and body composition without
Angelica Amorim Amato, Hailey Brit Wheeler, and Bruce Blumberg
and secondary sexual characteristics during puberty . International Journal of Hygiene and Environmental Health 2015 218 603 – 615 . ( https://doi.org/10.1016/j.ijheh.2015.06.004 ) 134 Golden R Gandy J Vollmer G A review of the endocrine
André Marques-Pinto and Davide Carvalho
axis is active in utero and during the first year of life (185) . Afterwards, gonadotropin secretion is reduced until puberty, when sequential endocrine changes set in motion the development of secondary sexual characteristics that will lead to
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