of the inositol-requiring enzyme 1–X-box-binding protein-1 pathway ( 42 ). In addition, modulations of the HSP pathway have been shown to suppress canonical TGF-β and NF-κB signaling. HSP72 blocks NF-κB activation at multiple aspects, such as by
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Tatsuya Kondo, Nobukazu Miyakawa, Sayaka Kitano, Takuro Watanabe, Rieko Goto, Mary Ann Suico, Miki Sato, Yuki Takaki, Masaji Sakaguchi, Motoyuki Igata, Junji Kawashima, Hiroyuki Motoshima, Takeshi Matsumura, Hirofumi Kai, and Eiichi Araki
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protein content was similar between groups ( Fig. 3C ). However, in adipose tissue, IH infusion augmented p-eIF2α protein levels and this was prevented by PBA ( P < 0.05, Fig. 4A ). Inositol requiring 1α (IRE1α) showed a similar profile to p-eIF2α
Davoud Jafari-Gharabaghlou, Mostafa Vaghari-Tabari, Hajar Oghbaei, Laura Lotz, Reza Zarezadeh, Yeganeh Rastgar Rezaei, Mahnaz Ranjkesh, Mohammad Nouri, Amir Fattahi, Saba Nikanfar, and Ralf Dittrich
, progesterone; PCNA, proliferating cell nuclear antigen; PI3K/AKT, phosphatidyl inositol-3-kinase/ protein kinase B; StAR, steroidogenic acute regulatory protein; STAT3, signal transducer and activator of transcription 3; TNF, tumor necrosis factor; uPA
Kjell Oberg, Eric Krenning, Anders Sundin, Lisa Bodei, Mark Kidd, Margot Tesselaar, Valentina Ambrosini, Richard P Baum, Matthew Kulke, Marianne Pavel, Jaroslaw Cwikla, Ignat Drozdov, Massimo Falconi, Nicola Fazio, Andrea Frilling, Robert Jensen, Klaus Koopmans, Tiny Korse, Dik Kwekkeboom, Helmut Maecke, Giovanni Paganelli, Ramon Salazar, Stefano Severi, Jonathan Strosberg, Vikas Prasad, Aldo Scarpa, Ashley Grossman, Annemeik Walenkamp, Mauro Cives, Irene Virgolini, Andreas Kjaer, and Irvin M Modlin
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Mojca Jensterle, Nika Aleksandra Kravos, Simona Ferjan, Katja Goricar, Vita Dolzan, and Andrej Janez
(metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility . Cochrane Database of Systematic Reviews 2012 CD003053 . ( https://doi.org/10.1002/14651858.CD003053.pub5 ) 16
Karim Gariani and François R Jornayvaz
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( 59 ). Combinatorial signals from the three core components of the UPR (protein kinase R-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1 (IRE1), and activating transcription factor 6 (ATF6)) initially trigger transcriptional
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