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Giovanni Tulipano

regulatory effects of hormones (leptin, ghrelin, insulin, adiponectin, GLP-1) on energy homeostasis. In summary, hypothalamic AMPK has a role in integrating peripheral signals with neural circuits, and its activation is related to increased food intake and

Open access

Gaëtan Prévost, Marie Picot, Marie-Anne Le Solliec, Arnaud Arabo, Hind Berrahmoune, Mouna El Mehdi, Saloua Cherifi, Alexandre Benani, Emmanuelle Nédélec, Françoise Gobet, Valéry Brunel, Jérôme Leprince, Hervé Lefebvre, Youssef Anouar, and Nicolas Chartrel

muscle tissue and the brain ( 1 ). In particular, accumulating evidence obtained during the last decade support the peripheral role of hypothalamic neuropeptides controlling feeding behaviour such as neuropeptide Y (NPY), orexins, ghrelin, corticotropin

Open access

Dorte Glintborg, Hanne Mumm, Jens Juul Holst, and Marianne Andersen

associated with decreased risk of RH and hence decreased appetite ( 9 ). Ghrelin levels decreased ( 19 ) and GLP-1 levels increased ( 6 ) after treatment with metformin in two uncontrolled studies in PCOS, which could have opposite effects on the risk of RH

Open access

Arno Téblick, Lies Langouche, and Greet Van den Berghe

thus the initiation of the interpulse-trough ( 9 ). On top of this straightforward interplay between two regulating hormones, a third key player in GH production is the in the stomach synthesized hormone ghrelin. Through binding with the GH secretagogue

Open access

Anna C Simcocks, Kayte A Jenkin, Lannie O’Keefe, Chrishan S Samuel, Michael L Mathai, Andrew J McAinch, and Deanne H Hryciw

), adiponectin (AdipoGen, Liestal, Switzerland), glucagon-like peptide 1 (GLP-1), ghrelin, leptin (Bioplex hormone immunoassay; Bio-Rad Laboratories), erythropoietin (EPO), growth regulated α protein/keratinocyte chemoattractant (GROC/KC), interferon gamma (IFN

Open access

Alexis Sudlow, Carel W le Roux, and Dimitri J Pournaras

PYY as well as decreased ghrelin following resection of the gastric fundus ( 20 , 21 ). Alterations in bile acids have also been demonstrated to be a significant contributory factor in animal models following SG ( 22 ). Since its adoption as a

Open access

Anastasia P Athanasoulia-Kaspar, Kathrin H Popp, and Gunter Karl Stalla

with prolactinomas could be attributed to ghrelin. Both patients with prolactinomas newly diagnosed and under ongoing cabergoline treatment but also healthy subjects were included. The study revealed no significant difference in terms of the ghrelin

Open access

Jose M Garcia, Beverly M K Biller, Márta Korbonits, Vera Popovic, Anton Luger, Christian J Strasburger, Philippe Chanson, Ronald Swerdloff, Christina Wang, Rosa Rosanna Fleming, Fredric Cohen, Nicola Ammer, Gilbert Mueller, Nicky Kelepouris, Frank Strobl, Vlady Ostrow, and Kevin C J Yuen

effects, including nausea, vomiting, and headache ( 19 ). Macimorelin is an orally active ghrelin receptor agonist that is indicated for the diagnosis of AGHD in the United States ( 26 ) and Europe ( 27 ). Macimorelin is well-tolerated; the most frequent

Open access

Juliane Léger, Anne Fjellestad-Paulsen, Anne Bargiacchi, Catherine Doyen, Emmanuel Ecosse, Jean-Claude Carel, and Marie-France Le Heuzey

involving the growth hormone (GH)-insulin-like growth factor-I (IGF-I) axis, thyroid function, hypercortisolemia, hypogonadotropic hypogonadism and the levels of several adipokines and gut peptides, such as ghrelin and peptide YY ( 2 ). The

Open access

Anette Lundqvist, Herbert Sandström, and Torbjörn Bäckström

during the luteal phase of ovulatory menstrual cycles . American Journal of Clinical Nutrition 1995 61 39 – 43 . 31 Cummings DE Frayo RS Marmonier C Aubert R Chapelot D. Plasma ghrelin levels and hunger scores in humans