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Farzaneh Rohani, Mohammad Reza Alai, Sedighe Moradi, and Davoud Amirkashani

treatment with growth hormone. Therefore, this study was conducted to find out whether boys with CDGP could attain their TH and PAH in adulthood or not. Material and methods Subjects and study design The study was approved by Iran University of

Open access

Annalisa Blasetti, Valeria Castorani, Nella Polidori, Ilaria Mascioli, Francesco Chiarelli, and Cosimo Giannini

under-insulinization ( 3 ). These effects are mainly related to the role of insulin in the regulation of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis. In fact, normal insulin secretion and adequate portal insulin levels are necessary

Open access

Ursula M M Costa, Carla R P Oliveira, Roberto Salvatori, José A S Barreto-Filho, Viviane C Campos, Francielle T Oliveira, Ivina E S Rocha, Joselina L M Oliveira, Wersley A Silva, and Manuel H Aguiar-Oliveira

Introduction Growth hormone (GH) and its principal mediator insulin-like growth factor 1 (IGF1) have important effects not only on the acquisition of normal body size, but also on metabolic and cardiovascular (CV) status (1) . GH and IGF1 have

Open access

Xi Wang and Qi Yu

(subjects 1, 2, and 4) and one experienced limping (subject 2). Six patients had skin dysplasia. Subject 4 experienced visual deficit, and subject 1 developed growth hormone hypersecretion. Subjects 2, 6, 9, and 10 (i.e., 40% of patients) showed functional

Open access

Pinaki Dutta, Bhuvanesh Mahendran, K Shrinivas Reddy, Jasmina Ahluwalia, Kim Vaiphei, Rakesh K Kochhar, Prakamya Gupta, Anand Srinivasan, Mahesh Prakash, Kanchan Kumar Mukherjee, Viral N Shah, Girish Parthan, and Anil Bhansali

Introduction Acromegaly is most commonly caused by a growth hormone (GH)-producing pituitary tumor and is potentially life-threatening if untreated. Early diagnosis and treatment of acromegaly result in increased longevity and better quality of life

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Rachel D C A Diniz, Renata M Souza, Roberto Salvatori, Alex Franca, Elenilde Gomes-Santos, Thiago O Ferrão, Carla R P Oliveira, João A M Santana, Francisco A Pereira, Rita A A Barbosa, Anita H O Souza, Rossana M C Pereira, Alécia A Oliveira-Santos, Allysson M P Silva, Francisco J Santana-Júnior, Eugênia H O Valença, Viviane C Campos, and Manuel H Aguiar-Oliveira

in adult hypopituitary growth hormone (GH)-deficient patients before and after GH replacement . Journal of Clinical Endocrinology and Metabolism 2010 95 74 – 81 . ( doi:10.1210/jc.2009-1326 ). 8 Di Somma C Pivonello R Pizza G De Rosa A

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Danielle Christine Maria van der Kaay, Anne Rochtus, Gerhard Binder, Ingo Kurth, Dirk Prawitt, Irène Netchine, Gudmundur Johannsson, Anita C S Hokken-Koelega, Miriam Elbracht, and Thomas Eggermann

. AD, autosomal dominant; AR, autosomal recessive; BWS, Beckwith–Wiedemann syndrome; GH, growth hormone; MLPA, multiplex ligation-dependent probe amplification; MS-MLPA, methylation-specific MLPA; NS, Noonan syndrome; SGA, small for gestational age; SNP

Open access

Marilena Nakaguma, Fernanda A Correa, Lucas S Santana, Anna F F Benedetti, Ricardo V Perez, Martha K P Huayllas, Mirta B Miras, Mariana F A Funari, Antonio M Lerario, Berenice B Mendonca, Luciani R S Carvalho, Alexander A L Jorge, and Ivo J P Arnhold

Introduction Congenital hypopituitarism (CH) is a rare disorder (incidence of 1:3500–10,000 births) defined by the deficiency of one or more pituitary hormones ( 1 , 2 ). Clinical presentation varies, ranging from isolated growth hormone

Open access

Monika Bilic, Huma Qamar, Akpevwe Onoyovwi, Jill Korsiak, Eszter Papp, Abdullah Al Mahmud, Rosanna Weksberg, Alison D Gernand, Jennifer Harrington, and Daniel E Roth

improve growth-related outcomes. The insulin-like growth factor (IGF) axis includes several signal and binding proteins, many of which are under the regulation of growth hormone. IGF-I is the primary regulator of fetal growth, and its circulating

Open access

Aleksandra Gilis-Januszewska, Łukasz Kluczyński, and Alicja Hubalewska-Dydejczyk

popularity of boxing and kickboxing, both of which are known to cause repetitive head trauma and thus pituitary insufficiency ( 53 ). In the study of 61 boxers, Tanriverdi found growth hormone deficiency in 15% of them (which correlated with a decreased