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Jan-Bernd Stukenborg, Kirsi Jahnukainen, Marsida Hutka, and Rod T Mitchell

in many other non-human primates, including the rhesus monkey and marmoset ( 7 , 8 ). In humans and non-human primates after the rise in gonadotrophins and testosterone during early infancy, there follows a period of relative HPG quiescence during

Open access

Bledar Daka, Thord Rosen, Per Anders Jansson, Lennart Råstam, Charlotte A Larsson, and Ulf Lindblad

Introduction Sex hormone-binding globulin (SHBG) is a circulating plasma globulin binding sex hormones, both oestradiol and testosterone and is produced primarily by the liver. In two recent studies, SHBG could predict type 2 diabetes (T2D) in

Open access

Karim Gariani and François R Jornayvaz

Testosterone - Testicles - Primary hypogonadism (congenital abnormalities, acquired diseases) - Secondary hypogonadism (pituitary disease (LH) or hypothalamic disease (GnRH)) Prolactin - Pituitary gland - Micro or macroprolactinoma - Stalk effect

Open access

Sarah Byberg, Jesper Futtrup, Mikkel Andreassen, and Jesper Krogh

-density lipoprotein (LDL), triglycerides (TRG), fasting plasma glucose, HOMA-IR, fasting serum insulin, glycated hemoglobin (HbA1c), plasma testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), high-sensitivity C-reactive protein (hsCRP) and

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Martin Zweifel, Beat Thürlimann, Salome Riniker, Patrik Weder, Roger von Moos, Olivia Pagani, Martin Bigler, Karin M Rothgiesser, Christiane Pilop, Hanne Hawle, Peter Brauchli, Coya Tapia, Wolfgang Schoenfeld, Cristiana Sessa, and for the Swiss Group for Clinical Cancer Research (SAKK)

Introduction For the treatment of breast cancer (BC), testosterone was already used extensively between the 1930s and 1960s with anecdotal tumour responses (especially in bone metastases) seen in up to 20% of treated women ( 1 , 2 , 3 , 4

Open access

Ahmet Uçar, Nurçin Saka, Firdevs Baş, Nihal Hatipoğlu, Rüveyde Bundak, and Feyza Darendeliler

blood samples for glucose and lipids (total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, and triglycerides (TGs)), serum insulin, LH, FSH, DHEAS, total testosterone, and high-sensitivity C

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Muriel Houang, Thao Nguyen-Khoa, Thibaut Eguether, Bettina Ribault, Séverine Brabant, Michel Polak, Irène Netchine, and Antonin Lamazière

, a mixture of the deuterated internal standard (IS) (150 µL containing 17-OHP-d8, testosterone-d4, D4-androstenedione (D4A)-d5, and 21-deoxycortisol (21-DF)-d8)) was added to 150 µL of serum. The solution was mixed and left standing for 5 min, and

Open access

T S Nilsen, L Thorsen, C Kirkegaard, I Ugelstad, S D Fosså, and T Raastad

E3 ligases promote ubiquitin conjugation of proteins destined for breakdown by the 26s proteasome ( 10 ). Removal of testosterone has been shown to increase the expression of muscle-specific E3 ligases ( 11 ), and this may also play a role in ADT

Open access

Richard J Auchus

with the recommendations of professional societies, and the guidance of the United States Food and Drug Administration. The AACE position statement systematically reviews the patterns of misuse for testosterone, growth hormone (rhGH), thyroxine and

Open access

Elena Galazzi, Paolo Duminuco, Mirella Moro, Fabiana Guizzardi, Nicoletta Marazzi, Alessandro Sartorio, Sabrina Avignone, Marco Bonomi, Luca Persani, and Maria Teresa Bonati

inhibin B and undetectable total testosterone (TTe) levels ( Table 1 ). He was normosmic at Brief-Smell Identification test (B-SIT) and normal central olfactory structures were confirmed using MRI. His karyotype was 46,XY. At the age of 15 years, he