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Johan Verhelst, Anders F Mattsson, Cecilia Camacho-Hübner, Anton Luger, and Roger Abs

Introduction It is now well-recognized that patients with adult-onset growth hormone deficiency (AO-GHD), apart from experiencing a poor quality of life (QoL), present with an increased risk of developing a metabolic syndrome (MetS) ( 1 , 2

Open access

Min Li, Ying Chen, Jingjing Jiang, Yan Lu, Zhiyi Song, Shengjie Zhang, Chao Sun, Hao Ying, Xiaofang Fan, Yuping Song, Jialin Yang, and Lin Zhao

Flier JS Hollenberg AN Maratos-Flier E . Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner . Journal of Biological Chemistry 2010 285 14078 – 14082 . (

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Peter Wolf, Alexandre Dormoy, Luigi Maione, Sylvie Salenave, Jacques Young, Peter Kamenický, and Philippe Chanson

Introduction Acromegaly results in a clinical syndrome following increased serum concentrations of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). If not adequately treated, GH excess is associated with increased morbidity and

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Mei Li, Yanfei Chen, Binrong Liao, Jing Tang, Jingzi Zhong, and Dan Lan

excluded. The prepubertal girls in the NC group were recruited from children undergoing physical examination in our hospital. A basal LH(B-LH) < 0.6 IU/L was considered as prepubertal hormone level ( 8 ). Evaluation of growth and development General

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Magdaléna Fořtová, Lenka Hanousková, Martin Valkus, Jana Čepová, Richard Průša, and Karel Kotaška

Introduction About 80–90% of primary hyperparathyroidism (pHPT) cases are caused by parathyroid adenoma. Long-term increased parathyroid hormone (PTH) secretion leads to a generalized disorder of calcium, phosphate and bone metabolism. The

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Marko Stojanovic, Zida Wu, Craig E Stiles, Dragana Miljic, Ivan Soldatovic, Sandra Pekic, Mirjana Doknic, Milan Petakov, Vera Popovic, Christian Strasburger, and Márta Korbonits

-Moreno CG Trudeau VL Harvey S . Co-storage and secretion of growth hormone and secretoneurin in retinal ganglion cells . General and Comparative Endocrinology 2015 220 124 – 132 . ( ) 25435278 10.1016/j

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Adrian F Daly, David A Cano, Eva Venegas-Moreno, Patrick Petrossians, Elena Dios, Emilie Castermans, Alvaro Flores-Martínez, Vincent Bours, Albert Beckers, and Alfonso Soto-Moreno

-IHC is a promising pathological marker for somatotropinoma growth and invasion, although this study suggests that its role in predicting hormonal responses to SSA in acromegaly appears to be limited. Improved focus on patients with large and aggressive

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Richard J Auchus

obtained with thyroxine therapy for severe hypothyroidism, estrogen for ovarian failure, growth hormone for pituitary dwarfism, and most recently, recombinant parathyroid hormone for hypoparathyroidism ( 2 ). These sweeping responses to properly

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Taísa A R Vicente, Ívina E S Rocha, Roberto Salvatori, Carla R P Oliveira, Rossana M C Pereira, Anita H O Souza, Viviane C Campos, Elenilde G Santos, Rachel D C Araújo Diniz, Eugênia H O Valença, Carlos C Epitácio-Pereira, Mario C P Oliveira, Andrea Mari, and Manuel H Aguiar-Oliveira

assistance. References 1 Vijayakumar A Yakar S LeRoith D . The intricate role of growth hormone in metabolism . Frontiers in Endocrinology 2011 2 32 . ( doi:10.3389/fendo.2011.00032 ). 2 Clemmons DR . The relative roles of growth hormone and

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Maryam Iravani, Marie K Lagerquist, Elham Karimian, Andrei S Chagin, Claes Ohlsson, and Lars Sävendahl

system ( 4 ). With regard to connective tissues, the expression of ESR1, ESR2 and GPER1 has previously been demonstrated in human bone and growth plate cartilage ( 8 , 9 ) as well as in rat spinal and tibial growth plate chondrocytes ( 10 ). Moreover