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Joana Simões-Pereira, Daniel Macedo, and Maria João Bugalho

. Those patients not eligible for surgery may undergo stereotaxic radiosurgery (SRS) or whole-brain radiotherapy (WBR). RAI can be considered for iodine-avid CNS metastases, under glucocorticoid therapy to minimize the TSH-induced effects and the

Open access

Ursula M M Costa, Carla R P Oliveira, Roberto Salvatori, José A S Barreto-Filho, Viviane C Campos, Francielle T Oliveira, Ivina E S Rocha, Joselina L M Oliveira, Wersley A Silva, and Manuel H Aguiar-Oliveira

risk is due to untreated GHD, or to confounding factors often found in acquired GHD. Some of these factors such as hypogonadism, excessive glucocorticoid replacement, craniopharyngioma, radiotherapy (implicated in cerebrovascular mortality or de novo

Open access

Emmanuelle Motte, Anya Rothenbuhler, Stephan Gaillard, Najiba Lahlou, Cécile Teinturier, Régis Coutant, and Agnès Linglart

after surgery, the patient still required glucocorticoid replacement. He was treated with growth hormone between the ages of 14 and 17 years because of severe growth retardation. His final height z -score is −1.5. During the mitotane treatment, he began

Open access

Rachel K Rowe, Benjamin M Rumney, Hazel G May, Paska Permana, P David Adelson, S Mitchell Harman, Jonathan Lifshitz, and Theresa C Thomas

feedback systems to glucocorticoids following TBI in the rat ( 33 ). Provocative testing, as accomplished in the rat by dexamethasone (DEX) administration followed by restraint stress, can be used to uncover damage to the HPE axis ( 33 , 35 ). The HPE axis

Open access

N Bergmann, F Gyntelberg, and J Faber

of glucocorticoids enhance hepatic gluconeogenesis and inhibit the secretion and action of insulin leading to insulin resistance (72, 73) . Second, glucocorticoids cause differentiation and proliferation of adipocytes and redistribution of fat

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Carolina Inda, Natalia G Armando, Paula A dos Santos Claro, and Susana Silberstein

stimulates the synthesis and release of glucocorticoids from the zona fasiculata of the adrenal cortex, cortisol in primates and corticosterone in rodents. The biological effects of glucocorticoids support the adaptation to stress-induced demands by

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Maria Stelmachowska-Banaś and Izabella Czajka-Oraniec

, high-doses of glucocorticoids (GCSs) ( 3 , 4 ), endocrine irAEs generally do not require cessation of ICI-treatment and rarely require high-dose GCS therapy, although long-term management may be required when persistent ( 5 , 6 ). Interestingly, the

Open access

Karim Gariani and François R Jornayvaz

an increased excretion of 5α-reduced steroids ( 83 ). The role of 5α-reductase is further discussed in the glucocorticoid excess section. Overall, women with PCOS show a high prevalence of NAFLD, even independently of obesity and dysglycemia

Open access

Hiren Patt, Katrin Koehler, Sailesh Lodha, Swati Jadhav, Chaitanya Yerawar, Angela Huebner, Kunal Thakkar, Sneha Arya, Sandhya Nair, Manjunath Goroshi, Hosahithlu Ganesh, Vijaya Sarathi, Anurag Lila, Tushar Bandgar, and Nalini Shah

patients, was second most prevalent disorder. Its prevalence was higher than what is classically reported in earlier reviews (75%) ( 1 ). AI in TAS is commonly isolated glucocorticoid deficiency. In their original report, Allgrove and coworkers described

Open access

Luca Persani, Biagio Cangiano, and Marco Bonomi

secretion: (a) glucocorticoids; (b) dopamine; (c) cocaine; (d) anti-epileptics; (e) anti-psychotics; (f) metformin Thyrotoxicosis-related conditions: Levothyroxine withdrawal syndrome, prolonged TSH suppression after recovery from thyrotoxicosis