androgens and testosterone are all decreased or absent. The urinary metabolites 17-hydroxylase corticosteroid and 17-ketosteroid also are decreased or absent. The diagnosis is set by markedly elevated levels of 11-deoxycorticosterone and corticosterone ( 43
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Efstratios Kardalas, Stavroula A Paschou, Panagiotis Anagnostis, Giovanna Muscogiuri, Gerasimos Siasos, and Andromachi Vryonidou
Tomás P Griffin, Caroline M Joyce, Sumaya Alkanderi, Liam M Blake, Derek T O’Keeffe, Delia Bogdanet, Md Nahidul Islam, Michael C Dennedy, John E Gillan, John J Morrison, Timothy O’Brien, John A Sayer, Marcia Bell, and Paula M O’Shea
pregnancy, the proband was treated with a combination of i.v. fluids, a diet low in calcium and vitamin D and oral corticosteroids. II.2 required numerous prolonged hospital admissions to maintain Ca 2+ levels within normal limits. The baby (III.3) had
A Daniel Bird, Spencer Greatorex, David Reser, Gareth G Lavery, and Timothy J Cole
‘GXXXGXG’ nucleotide cofactor (NAD + /NADP + ) binding domain and an ‘YXXXK’ catalytic active site domain ( 4 ). 11βHSD1 and 11βHSD2 carry out largely opposing roles in the preceptor modification of corticosteroids. 11βHSD1, encoded by the HSD11B1 gene
Charlotte Höybye, Beverly M K Biller, Jean-Marc Ferran, Murray B Gordon, Nicky Kelepouris, Navid Nedjatian, Anne H Olsen, and Matthias M Weber
patients (38.6%) were reported to be taking thyroid hormone and 322 patients (45.4%) were reported as taking corticosteroids at baseline and/or during the follow-up years. Table 1 Baseline demographics and clinical characteristics of all patients
Pernille H Hellmann, Jonatan I Bagger, Katrine R Carlander, Katrine B Hansen, Julie L Forman, Joachim Størling, Elizaveta Chabanova, Jens Holst, Tina Vilsbøll, and Filip K Knop
Introduction Prednisolone, a corticosteroid-based drug, is used in a wide range of diseases due to its anti-inflammatory and immunosuppressant effects ( 1 , 2 , 3 , 4 ). Glucocorticoids affect various human tissues, and it has been shown
M Boering, P R van Dijk, S J J Logtenberg, K H Groenier, B H R Wolffenbuttel, R O B Gans, N Kleefstra, and H J G Bilo
. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma . Journal of Clinical Endocrinology and Metabolism 1981 53 58 – 68 . ( doi:10.1210/jcem-53
Sweta Budyal, Swati Sachin Jadhav, Rajeev Kasaliwal, Hiren Patt, Shruti Khare, Vyankatesh Shivane, Anurag R Lila, Tushar Bandgar, and Nalini S Shah
. Discriminatory features included easy bruising, facial plethora, proximal muscle weakness, and/or striae (especially if reddish purple and >1 cm wide). Patients with a history of exogenous corticosteroid intake, pregnant women, women using oral contraceptive (OC
M S Elston, V B Crawford, M Swarbrick, M S Dray, M Head, and J V Conaglen
–3 weeks for mouth ulcers but reported no oral, inhaled or parenteral corticosteroid use. On examination, the patient was hypertensive (BP 154/74 mmHg), euphoric and grossly oedematous with bilateral pitting oedema to the mid-shins and mild facial oedema
Fiona Broughton Pipkin, Hiten D Mistry, Chandrima Roy, Bernhard Dick, Jason Waugh, Rebecca Chikhi, Lesia O Kurlak, and Markus G Mohaupt
corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth . Cochrane Database of Systematic Reviews 2006 CD004454 . ( doi:10.1002/14651858.CD004454.pub2 ). 17 Heckmann M Hartmann MF Kampschulte B Gack H Bodeker RH
Kathrin Zopf, Kathrin R Frey, Tina Kienitz, Manfred Ventz, Britta Bauer, and Marcus Quinkler
Journal of Endocrinology 2009 160 233 – 237 . ( doi:10.1530/EJE-08-0550 ) 19011006 16 Ai J Guo L Zheng Z Wang SX Huang B Li XA. Corticosteroid therapy benefits septic mice with adrenal insufficiency but harms septic mice without adrenal