hormone-binding globulin (SHBG) or weakly bound to albumin, orosomucoid and corticosteroid-binding globulin ( 2 ). Only 1–4% circulates as free testosterone, which is considered to be the biologically active component ( 2 , 3 ). Determination of free
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M P Schuijt, C G J Sweep, R van der Steen, A J Olthaar, N M M L Stikkelbroeck, H A Ross, and A E van Herwaarden
Johanna Christina Penell, Mark M Kushnir, Lars Lind, Jonatan Bergquist, Jonas Bergquist, P Monica Lind, and Tord Naessen
sensitivity of the assays was 0.5 nmol/L. Statistical analyses Subjects on current corticosteroid treatment and on previous or current hormone therapy were excluded. Demographic data are presented as median and range, or percentage. Steroid
Janko Sattler, Jinwen Tu, Shihani Stoner, Jingbao Li, Frank Buttgereit, Markus J Seibel, Hong Zhou, and Mark S Cooper
thank the Molecular Physiology Unit team of the ANZAC Research Institute for care of the experimental mice. Thanks to Ling Zhuang who assisted with genotyping. References 1 Cooper MS Stewart PM . Corticosteroid insufficiency in acutely ill
Sarah Ying Tse Tan, Hong Chang Tan, Ling Zhu, Lih Ming Loh, Dawn Shao Ting Lim, Du Soon Swee, Yoke Ling Chan, Huee Boon Lim, Shiau Lee Ling, En Jun Ou, Wynn Ee Teo, Xiao Ping Zhang, Hui Fen Goh, and Peng Chin Kek
primary adrenal insufficiency: an Endocrine Society clinical practice guideline . Journal of Clinical Endocrinology and Metabolism 2016 101 364 – 389 . ( https://doi.org/10.1210/jc.2015-1710 ) 26760044 4 Brien TG . Human corticosteroid binding
Keina Nishio, Akiko Tanabe, Risa Maruoka, Kiyoko Nakamura, Masaaki Takai, Tatsuharu Sekijima, Satoshi Tunetoh, Yoshito Terai, and Masahide Ohmichi
explained by trauma such as those occurring during motor-vehicle accidents, corticosteroid drug use, hormone replacement therapy, use of oral contraceptives for a period longer that 6 months, past or recent use of hormone therapy) were excluded from this
Eva Novoa, Marcel Gärtner, and Christoph Henzen
3 401 – 406 . ( doi:10.1097/MAO.0b013e318161aaae ). 2 Rauch SD Halpin CF Antonelli PJ Babu S Carey JP Gantz BJ Goebel JA Hammerschlag PE Harris JP Isaacson B . Oral vs intratympanic corticosteroid therapy for idiopathic
Bledar Daka, Thord Rosen, Per Anders Jansson, Lennart Råstam, Charlotte A Larsson, and Ulf Lindblad
1988 78 539 – 545 . ( doi:10.1161/01.CIR.78.3.539 ). 4 Lapidus L Lindstedt G Lundberg PA Bengtsson C Gredmark T . Concentrations of sex-hormone binding globulin and corticosteroid binding globulin
C E Higham, A Olsson-Brown, P Carroll, T Cooksley, J Larkin, P Lorigan, D Morganstein, P J Trainer, and the Society for Endocrinology Clinical Committee
. Diabetes Care 2015 38 e55 – e57 . ( https://doi.org/10.2337/dc14-2349 ) 10.2337/dc14-2349) 16 Min L Hodi F Giobbie-Hurder A Ott PA Luke JJ Donahue H Davis M Carroll RS Kaiser UB . Systemic high-dose corticosteroid treatment does
Fernando Aprile-Garcia, María Antunica-Noguerol, Maia Ludmila Budziñski, Ana C Liberman, and Eduardo Arzt
. ( doi:10.1038/nrn2297 ). 10 Besedovsky HO del Rey A . Immune–neuroendocrine circuits: integrative role of cytokines . Frontiers in Neuroendocrinology 1992 13 61 – 94 . 11 De Kloet ER Vreugdenhil E Oitzl MS Joels M . Brain corticosteroid receptor
Jana Ernst, Katharina Gert, Frank Bernhard Kraus, Ulrike Elisabeth Rolle-Kampczyk, Martin Wabitsch, Faramarz Dehghani, and Kristina Schaedlich
conditions, androgens (androstenedione, androsterone, testosterone, dihydrotestosterone, etiocholanolone) and corticosteroids (corticosterone, aldosterone, 11-deoxycortisol, cortisol, cortisone) increased during adipogenesis. Furthermore, an androstenedione