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Rachel K Rowe, Benjamin M Rumney, Hazel G May, Paska Permana, P David Adelson, S Mitchell Harman, Jonathan Lifshitz, and Theresa C Thomas

. Dexamethasone treatment At 56 DPI, rats were administered a subcutaneous dose of 0.1mg/kg dexamethasone (DEX) (Dexamethasone Injectable sc-362917Rx, Santa Cruz Biotechnology) at approximately 06:00h to investigate effectiveness of HPA axis negative feedback

Open access

Veronica Kieffer, Kate Davies, Christine Gibson, Morag Middleton, Jean Munday, Shashana Shalet, Lisa Shepherd, and Phillip Yeoh

• Understands the pathophysiology of the normal hypothalamic-pituitary-adrenal (HPA) axis and recognises deviation from the norm • Is able to identify abnormal test results and escalate appropriately a,b,c • Can understand false-positive and -negative

Open access

Muriel Houang, Thao Nguyen-Khoa, Thibaut Eguether, Bettina Ribault, Séverine Brabant, Michel Polak, Irène Netchine, and Antonin Lamazière

D Banerji D . The effects of intranasal triamcinolone acetonide and intranasal fluticasone propionate on short-term bone growth and HPA axis in children with allergic rhinitis . Annals of Allergy, Asthma and Immunology 2003 90 56 – 62 . ( https

Open access

N Bergmann, F Gyntelberg, and J Faber

-response is then initiated with activation of the hypothalamic–pituitary–adrenal (HPA) axis and the sympathetic–adrenomedullar (SAM) axis (3) . The activation of the two axes takes place in order to maintain the dynamic balance of the body, homeostasis, and

Open access

Maximilian Bielohuby, Martin Bidlingmaier, and Uwe Schwahn

rodent studies and data are usually only reported for individual hormones. Among the reported hormones, particular attention has been given to hormones belonging to the hypothalamic-pituitary-adrenal (HPA) axis as well as to adrenal medullary hormones

Open access

Legh Wilkinson, Nicolette J D Verhoog, and Ann Louw

Introduction Due to the interrelatedness of the stress and inflammatory responses, chronic persistent inflammation may be considered both a cause and a consequence of a prolonged disruption of the central HPA axis, a systemic signalling

Open access

Sirazum Choudhury, Tricia Tan, Katharine Lazarus, and Karim Meeran

-pituitary-adrenal (HPA) axis, the influence of the master clock is exerted by canonical endocrine signalling via arginine vasopressin (AVP) modification of pulsatile ACTH secretion, but there also exist non-endocrine pathways with neural signalling via the splanchnic

Open access

Efstratios Kardalas, Stavroula A Paschou, Panagiotis Anagnostis, Giovanna Muscogiuri, Gerasimos Siasos, and Andromachi Vryonidou

hyperactivity of the hypothalamus–pituitary–adrenal (HPA) axis ( 49 ). Due to elevated ACTH, patients suffer from an overproduction of mineralocorticoids, leading to hypertension, hypokalemic alkalosis and fatigue. Females also show signs of hyperandrogenism

Open access

Andrew R Dismukes, Vanessa J Meyer, Elizabeth A Shirtcliff, Katherine P Theall, Kyle C Esteves, and Stacy S Drury

patterns of allostasis? An examination of basal and stress reactive HPA axis activity and telomere length . Physiology & Behavior 2012 106 40 – 45 . ( doi:10.1016/j.physbeh.2011.11.016 ) 25 Kalimi M Shafagoj Y Loria R Padgett D

Open access

Andrea V Haas, Paul N Hopkins, Nancy J Brown, Luminita H Pojoga, Jonathan S Williams, Gail K Adler, and Gordon H Williams

used various cortisol measurement techniques (morning plasma, salivary, post-dexamethasone suppression, 24-h urine) that assess distinct aspects of the hypothalamic–pituitary–axis. An emerging new technique that may also be of use is measurement of hair