New Avenues in Male Reproductive Health
Male infertility and male hypogonadism are common reproductive disorders that present in different forms, affecting many aspects of health. However, recent studies have uncovered new ways to improve men's reproductive health. For example, mapping of genetic pathways and novel molecular approaches have allowed us to interrogate mechanisms underlying testicular function which lead to pathology. These may also lead to the development of novel drug therapies to modulate testicular function.
This timely special collection will pull together an array of research focused on improving the treatment of male reproductive disorders. It will cover topics including:
- Genetic disorders in male infertility, including genetics of hypogonadotropic hypogonadism
- Sperm maturation during transport through the male reproductive tract
- Environmental threats for male reproductive health
- Dysregulation of testicular function by obesity or diabetes
- Novel seminal or sperm diagnostic markers of male reproductive function
- Putative therapeutic targets or therapies for male infertility
- Efficacy of treatment with FSH for infertile male patients
- Sperm methylome/transcriptome/proteome and embryo development/offspring health
- Microbiome and reproductive health
- In vitro spermatogenesis.
“This collection has the potential to bring together studies from the latest and most interesting lines of research, promising a better understanding of the causes of male infertility and the identification of new therapeutic approaches.” – Collection editor, Professor Aldo Calogero.
This collection has partnered with 'Reproductive Endocrinology 2024' , an annual event from the Society for Endocrinology.
Read the articles published in the collection:
Early adolescence assessment of eleven boys treated with continuous subcutaneous infusion (CSGI) of recombinant LH and FSH during infancy
Anne-Sophie Lambert, Trouvin Marie-Agathe, Khadidja Fouatih, Adrien Lecoeuvre, Cecile Thomas-Teinturier, Anya Rothenbuhler, Jerome Bouligand, Séverine Trabado, Agnès Linglart, and Claire Bouvattier
Gonadal function in patients with 47,XYY syndrome: a systematic review and meta-analysis
Rossella Cannarella, Andrea Pedano, Michele Compagnone, Sandro La Vignera, Rosita A. Condorelli, and Aldo E. Calogero
From biological marker to clinical application: the role of anti-Müllerian hormone (AMH) for delayed puberty and idiopathic non-obstructive azoospermia in males
Zeng Yuanyuan, Zhao Guicheng, Zheng Yi, and Xiaohui Jiang
Association of leukocyte elastase in semen and seminal plasma with sperm parameters and pregnancy outcomes in male fertility
Mausumi Das, Maha Gumssani, Julia Mullaney, Ralf Henkel, Suks Minhas, Marie Claire Aquilina, and Channa N Jayasena
Testosterone therapy-induced erythrocytosis: can phlebotomy be justified?
Peter Bond, Tijs Verdegaal, and Diederik L Smit
LIN28B expression is downregulated in mature spermatozoa of oligozoospermic men and associates with genetic variants previously linked to pubertal onset
Maria Cecilia Lardone, Marina Diaz-Fontdevila, Eliana Ortiz, German Iniguez, Pamela Inostroza, Cristobal Espinoza, Mauricio Ebensperger, Kristian Almstrup, and Andrea Castro
Collection Editors:
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Dr. Channa Jayasena – Guest Editor Dr Jayasena is a Reader in Reproductive Endocrinology at Imperial College London, where he currently leads a research team. Dr Jayasena works as a Consultant in Reproductive Endocrinology and Head of Andrology at St. Mary's Hospital and Hammersmith Hospital, London. |
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Dr. Anu Sironen – Guest Editor Dr. Sironen, University College London (UCL), is currently working on a UK Biotechnology and Biological Sciences Research Council (BBSRC) funded research project to understand the cilia related causes and mechanisms in male infertility. She is a Senior Research Scientist at UCL and Natural Resources Institute Finland, where her studies have identified several genetic causes of male infertility in animal models and in human patients. |
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Professor Aldo E. Calogero, M.D. – Guest Editor Professor Calogero is a Full Professor of Endocrinology at the University of Catania, Catania, Italy. He is Director of the Division of Endocrinology, Metabolic Diseases and Nutrition of the German University Hospital Policlinico “G. Rodolico – San Marco”, Catania, Italy. |
